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• W2529359263 abstract "Phase-shift perfluorocarbon droplets have been investigated for over 20 years as pre-clinical ultrasound contrast agents with distinctive advantages in imaging and therapy. A number of formulation strategies exist, each with inherent advantages and limitations. In this note, we demonstrate a unique opportunity: that phase-shift droplets can be generated directly from commercially available microbubbles. This may facilitate pre-clinical and translational development by reducing the in-house synthesis expertise and resources required to generate high concentration droplet emulsions. Proof-of-principle in vitro and in vivo is given using droplets created from Definity and MicroMarker. The results demonstrate the role of perfluorocarbon choice in the trade-off between thermal stability and vaporization threshold, and suggest that commercial microbubbles with decafluorobutane cores may be ideal for this approach." @default.
• W2529359263 created "2016-10-14" @default.
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• W2529359263 date "2017-02-01" @default.
• W2529359263 modified "2023-10-18" @default.
• W2529359263 title "More Than Bubbles: Creating Phase-Shift Droplets from Commercially Available Ultrasound Contrast Agents" @default.
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• W2529359263 doi "https://doi.org/10.1016/j.ultrasmedbio.2016.09.003" @default.
• W2529359263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27727022" @default.
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