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- W2529437112 abstract "Introduction: Emphysema is a progressive disease, and the lobes of severe emphysema patients typically contain segments with substantially more disease than other segments within the lobe.Objective: Prove thermal vapor treatment of the most diseased segments in a step-wise manner, results in clinically meaningful improvement in FEV1 % predicted, SGRQ and 6MWD.Methods: 69 patient, multi-national, 2:1 RCT comparing segmental ablation vs. medical management. Treat 1 upper lobe segment followed by treatment of 1 – 2 segments of an upper lobe in Gold stage III/IV patients.Results: Exacerbation and pneumonia rates were in the range of expectation for bronchoscopic lung volume reduction therapies and were 24% and 18% at 6 months post treatment respectively. ![Figure][1] Conclusions: Treating the most diseased segments results in clinically meaningful improvement in FEV1, SGRQ, and 6MWD while sparing healthier segments. Thermal Vapor is safe with no chest tube insertion or surgery. Finally, treating in a step-wise manner leaves additional segments for possible treatment over time. [1]: pending:yes" @default.
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- W2529437112 date "2015-09-01" @default.
- W2529437112 modified "2023-10-02" @default.
- W2529437112 title "LATE-BREAKING ABSTRACT: Treating the most diseased segments in patients with severe emphysema: 6 month results from the STEP-UP randomized controlled trial (RCT)" @default.
- W2529437112 doi "https://doi.org/10.1183/13993003.congress-2015.pa4864" @default.
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