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- W2529516941 abstract "The current criterion for evaluating antiangiogenic efficacy is insufficient as tumor shrinkage occurs after blood perfusion decreases. Computed tomography perfusion imaging might predict the status of angiogenesis. The present study aimed to investigate Effect of Endostar combined with radiation therapy for esophageal squamous cell carcinoma on tumor tissue perfusion and efficacy. Forty-five cases with esophageal carcinoma were divided randomly into two groups, radiation therapy alone (RT Group) and Endostar combined with radiation therapy group (RT + E Group). There was no difference of radiation therapy between the two groups. The cases of RT + E group accepted Endostar 7.5mg/m2 qd for 2 weeks during the radiation. In the two groups, the data of blood flow (BF), blood volume (BV) increased, and mean transit time (MTT) decreased with statistical significance after radiation therapy (P<0.05). However, after radiation therapy, the RT + E Group showed significantly higher BF (81.08 ml/100g/min vs 72.14 ml/100g/min P = 0.01) than RT Group. However, the BF (3.97 ml/100g vs 3.48 ml/100g P = 0.051) and MTT (9.87s vs 8.51s P = 0.046) had no significant difference in the two groups. For early efficacy, RT + E Group achieved a higher total response rate than RT Group (95.7% vs 85.8% P<0.05). Endostar combined with radiation therapy can improve the BF and outcome of esophageal carcinoma, but the tumor BV and MTT was not significantly improved." @default.
- W2529516941 created "2016-10-14" @default.
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- W2529516941 date "2016-10-01" @default.
- W2529516941 modified "2023-10-16" @default.
- W2529516941 title "Effect of Endostar Combined With Radiation Therapy for Esophageal Squamous Cell Carcinoma on Blood Perfusion and Early Efficacy" @default.
- W2529516941 doi "https://doi.org/10.1016/j.ijrobp.2016.06.1135" @default.
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