Matches in SemOpenAlex for { <https://semopenalex.org/work/W2529654427> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2529654427 abstract "For decades the effect of ionizing radiation on DNAhas been an active field of research. Understanding the fundamentalmechanisms of radiation damage to DNA is essential for predictingdamage distribution in biologically relevant sequences and for thedevelopment of important medical applications, such as increasingradiation therapy efficacy. The chemical reactions that result fromthe direct deposition of energy from ionizing radiation into DNAare known as direct-type radiation damage. This can be furthercategorized as single-track or multiple-track, depending on theaverage number of radiation tracks that a target is exposed to. Todate a large amount of work has been focused on the initial eventsresulting from low radiation doses, which produce predominantlysingle-track radiation chemistry. In this study, ElectronParamagnetic Resonance (EPR) spectra of oligodeoxynucleotide (ODN)powders were collected after x-irradiating samples over a largedose range (2-400 kGy) in order to follow both single- andmultiple-track radiation chemistry in a controlled manner.Principle component analysis of EPR spectra from samples exposed tolow doses (2-50 kGy) yielded important results on the initialdistribution of free radicals caused by single-track events andrevealed important charge transfer properties in addition toidentifying an electron scavenging contaminant found in synthesizedDNA oligomers. EPR spectra of ODN powders at high dose (400 kGy)allowed the study of complex damage that occurs in radiation spurswhere multiple-track events are likely. These results were used todevelop a comprehensive model for single- and multiple-trackradical chemistry in organic molecules. This model was also appliedto proteins where it gave new insights into the mechanism ofcrystal death and, more importantly, into the conformationalchanges likely to occur in crystallized proteins during modernx-ray crystallographic experiments. High dose studies resulted inimportant observations including the discovery of a novelthermally-independent pathway for multiply reduced DNA bases andproteins. Our model for predicting radiation damage in biomoleculeshas implications for cancer risk assessment and treatment, as wellas the development of improved techniques for x-raycrystallography." @default.
- W2529654427 created "2016-10-14" @default.
- W2529654427 creator A5010095960 @default.
- W2529654427 creator A5075153396 @default.
- W2529654427 date "2012-01-01" @default.
- W2529654427 modified "2023-09-27" @default.
- W2529654427 title "Distribution and Evolution of Free Radicals in DNA and Protein Powders: Multiple-Track Radiation Chemistry" @default.
- W2529654427 hasPublicationYear "2012" @default.
- W2529654427 type Work @default.
- W2529654427 sameAs 2529654427 @default.
- W2529654427 citedByCount "0" @default.
- W2529654427 crossrefType "journal-article" @default.
- W2529654427 hasAuthorship W2529654427A5010095960 @default.
- W2529654427 hasAuthorship W2529654427A5075153396 @default.
- W2529654427 hasConcept C111337013 @default.
- W2529654427 hasConcept C111919701 @default.
- W2529654427 hasConcept C120665830 @default.
- W2529654427 hasConcept C121332964 @default.
- W2529654427 hasConcept C1276947 @default.
- W2529654427 hasConcept C139066938 @default.
- W2529654427 hasConcept C147120987 @default.
- W2529654427 hasConcept C153385146 @default.
- W2529654427 hasConcept C153428861 @default.
- W2529654427 hasConcept C177322064 @default.
- W2529654427 hasConcept C178790620 @default.
- W2529654427 hasConcept C18231593 @default.
- W2529654427 hasConcept C185544564 @default.
- W2529654427 hasConcept C185592680 @default.
- W2529654427 hasConcept C187961010 @default.
- W2529654427 hasConcept C34667332 @default.
- W2529654427 hasConcept C41008148 @default.
- W2529654427 hasConcept C46141821 @default.
- W2529654427 hasConcept C4839761 @default.
- W2529654427 hasConcept C86611320 @default.
- W2529654427 hasConcept C89992363 @default.
- W2529654427 hasConceptScore W2529654427C111337013 @default.
- W2529654427 hasConceptScore W2529654427C111919701 @default.
- W2529654427 hasConceptScore W2529654427C120665830 @default.
- W2529654427 hasConceptScore W2529654427C121332964 @default.
- W2529654427 hasConceptScore W2529654427C1276947 @default.
- W2529654427 hasConceptScore W2529654427C139066938 @default.
- W2529654427 hasConceptScore W2529654427C147120987 @default.
- W2529654427 hasConceptScore W2529654427C153385146 @default.
- W2529654427 hasConceptScore W2529654427C153428861 @default.
- W2529654427 hasConceptScore W2529654427C177322064 @default.
- W2529654427 hasConceptScore W2529654427C178790620 @default.
- W2529654427 hasConceptScore W2529654427C18231593 @default.
- W2529654427 hasConceptScore W2529654427C185544564 @default.
- W2529654427 hasConceptScore W2529654427C185592680 @default.
- W2529654427 hasConceptScore W2529654427C187961010 @default.
- W2529654427 hasConceptScore W2529654427C34667332 @default.
- W2529654427 hasConceptScore W2529654427C41008148 @default.
- W2529654427 hasConceptScore W2529654427C46141821 @default.
- W2529654427 hasConceptScore W2529654427C4839761 @default.
- W2529654427 hasConceptScore W2529654427C86611320 @default.
- W2529654427 hasConceptScore W2529654427C89992363 @default.
- W2529654427 hasLocation W25296544271 @default.
- W2529654427 hasOpenAccess W2529654427 @default.
- W2529654427 hasPrimaryLocation W25296544271 @default.
- W2529654427 hasRelatedWork W130208598 @default.
- W2529654427 hasRelatedWork W139769396 @default.
- W2529654427 hasRelatedWork W1531123976 @default.
- W2529654427 hasRelatedWork W1976354124 @default.
- W2529654427 hasRelatedWork W1980612081 @default.
- W2529654427 hasRelatedWork W1991688352 @default.
- W2529654427 hasRelatedWork W2009270973 @default.
- W2529654427 hasRelatedWork W2048147004 @default.
- W2529654427 hasRelatedWork W2065794198 @default.
- W2529654427 hasRelatedWork W2092822342 @default.
- W2529654427 hasRelatedWork W2166612143 @default.
- W2529654427 hasRelatedWork W2319328177 @default.
- W2529654427 hasRelatedWork W2521069550 @default.
- W2529654427 hasRelatedWork W2751219200 @default.
- W2529654427 hasRelatedWork W2782170081 @default.
- W2529654427 hasRelatedWork W2799975902 @default.
- W2529654427 hasRelatedWork W2805397400 @default.
- W2529654427 hasRelatedWork W2810689754 @default.
- W2529654427 hasRelatedWork W2951883702 @default.
- W2529654427 hasRelatedWork W45489902 @default.
- W2529654427 isParatext "false" @default.
- W2529654427 isRetracted "false" @default.
- W2529654427 magId "2529654427" @default.
- W2529654427 workType "article" @default.