Matches in SemOpenAlex for { <https://semopenalex.org/work/W2529777799> ?p ?o ?g. }
- W2529777799 endingPage "319" @default.
- W2529777799 startingPage "310" @default.
- W2529777799 abstract "To describe the effects of type 1 diabetes on bone cells.Type 1 diabetes (T1D) is associated with low bone mineral density, increased risk of fractures, and poor fracture healing. Its effects on the skeleton were primarily attributed to impaired bone formation, but recent data suggests that bone remodeling and resorption are also compromised. The hyperglycemic and inflammatory environment associated with T1D impacts osteoblasts, osteocytes, and osteoclasts. The mechanisms involved are complex; insulinopenia, pro-inflammatory cytokine production, and alterations in gene expression are a few of the contributing factors leading to poor osteoblast activity and survival and, therefore, poor bone formation. In addition, the observed sclerostin level increase accompanied by decreased osteocyte number and enhanced osteoclast activity in T1D results in uncoupling of bone remodeling. T1D negatively impacts osteoblasts and osteocytes, whereas its effects on osteoclasts are not well characterized, although the limited studies available indicate increased osteoclast activity, favoring bone resorption." @default.
- W2529777799 created "2016-10-14" @default.
- W2529777799 creator A5021089004 @default.
- W2529777799 creator A5028345100 @default.
- W2529777799 creator A5034194433 @default.
- W2529777799 creator A5042641990 @default.
- W2529777799 creator A5072309257 @default.
- W2529777799 date "2016-10-04" @default.
- W2529777799 modified "2023-09-23" @default.
- W2529777799 title "Effects of Type 1 Diabetes on Osteoblasts, Osteocytes, and Osteoclasts" @default.
- W2529777799 cites W101739452 @default.
- W2529777799 cites W1582849500 @default.
- W2529777799 cites W1652067119 @default.
- W2529777799 cites W1864784836 @default.
- W2529777799 cites W1905240610 @default.
- W2529777799 cites W1922572604 @default.
- W2529777799 cites W1927141023 @default.
- W2529777799 cites W1949087596 @default.
- W2529777799 cites W1955614201 @default.
- W2529777799 cites W1971676948 @default.
- W2529777799 cites W1971706608 @default.
- W2529777799 cites W1971887776 @default.
- W2529777799 cites W1972724626 @default.
- W2529777799 cites W1978783778 @default.
- W2529777799 cites W1981865349 @default.
- W2529777799 cites W1983167741 @default.
- W2529777799 cites W1985366141 @default.
- W2529777799 cites W1986214667 @default.
- W2529777799 cites W1988533223 @default.
- W2529777799 cites W1990773585 @default.
- W2529777799 cites W1992208052 @default.
- W2529777799 cites W1993159515 @default.
- W2529777799 cites W1994416294 @default.
- W2529777799 cites W1999650748 @default.
- W2529777799 cites W2001489577 @default.
- W2529777799 cites W2009950788 @default.
- W2529777799 cites W2010675393 @default.
- W2529777799 cites W2012701249 @default.
- W2529777799 cites W2013339414 @default.
- W2529777799 cites W2014510338 @default.
- W2529777799 cites W2014566205 @default.
- W2529777799 cites W2019593546 @default.
- W2529777799 cites W2022798444 @default.
- W2529777799 cites W2022864901 @default.
- W2529777799 cites W2025768760 @default.
- W2529777799 cites W2028545958 @default.
- W2529777799 cites W2032107044 @default.
- W2529777799 cites W2033864326 @default.
- W2529777799 cites W2034766119 @default.
- W2529777799 cites W2036373185 @default.
- W2529777799 cites W2037154438 @default.
- W2529777799 cites W2037976951 @default.
- W2529777799 cites W2038349910 @default.
- W2529777799 cites W2038796191 @default.
- W2529777799 cites W2039421524 @default.
- W2529777799 cites W2041638197 @default.
- W2529777799 cites W2042361253 @default.
- W2529777799 cites W2042746603 @default.
- W2529777799 cites W2046317276 @default.
- W2529777799 cites W2053494903 @default.
- W2529777799 cites W2055517745 @default.
- W2529777799 cites W2056611129 @default.
- W2529777799 cites W2056784246 @default.
- W2529777799 cites W2057961407 @default.
- W2529777799 cites W2062255368 @default.
- W2529777799 cites W2063702173 @default.
- W2529777799 cites W2067129198 @default.
- W2529777799 cites W2067171323 @default.
- W2529777799 cites W2070223747 @default.
- W2529777799 cites W2070821151 @default.
- W2529777799 cites W2072593601 @default.
- W2529777799 cites W2077542254 @default.
- W2529777799 cites W2082735845 @default.
- W2529777799 cites W2083509197 @default.
- W2529777799 cites W2084883662 @default.
- W2529777799 cites W2085016903 @default.
- W2529777799 cites W2086174117 @default.
- W2529777799 cites W2086732436 @default.
- W2529777799 cites W2087642042 @default.
- W2529777799 cites W2089363189 @default.
- W2529777799 cites W2095703370 @default.
- W2529777799 cites W2109646477 @default.
- W2529777799 cites W2110192799 @default.
- W2529777799 cites W2114764486 @default.
- W2529777799 cites W2119551577 @default.
- W2529777799 cites W2122901687 @default.
- W2529777799 cites W2126052469 @default.
- W2529777799 cites W2128921346 @default.
- W2529777799 cites W2133514604 @default.
- W2529777799 cites W2134793345 @default.
- W2529777799 cites W2139055053 @default.
- W2529777799 cites W2149719379 @default.
- W2529777799 cites W2149918048 @default.
- W2529777799 cites W2153502260 @default.
- W2529777799 cites W2155907836 @default.
- W2529777799 cites W2155971182 @default.
- W2529777799 cites W2158169772 @default.
- W2529777799 cites W2161882340 @default.