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• W2529842825 abstract "The C. elegans excretory cell (EC) is a powerful model for tubulogenesis, a conserved process that requires precise cytoskeletal regulation. EXC-6, an ortholog of the disease-associated formin INF2, coordinates cell outgrowth and lumen formation during EC tubulogenesis by regulating F-actin at the tip of the growing canal and the dynamics of basolateral microtubules. EXC-6 functions in parallel to EXC-5/FGD, a predicted activator of the Rho GTPase Cdc42. Here we identify the parallel pathway: EXC-5 functions through CDC-42 to regulate two other formins: INFT-2, another INF2 ortholog, and CYK-1, the sole ortholog of mammalian Diaphanous (mDia). We show that INFT-2 promotes F-actin accumulation in the EC, and that CYK-1 inhibits INFT-2 to regulate F-actin levels and EXC-6-promoted outgrowth. As INF2 and mDia physically interact and cross-regulate in cultured cells, our work indicates that a conserved exc-5/FGD-Cdc42 pathway modulates this regulatory interaction and that it is functionally important in vivo during tubulogenesis." @default.
• W2529842825 created "2016-10-14" @default.
• W2529842825 creator A5057192752 @default.
• W2529842825 creator A5069328543 @default.
• W2529842825 date "2016-01-01" @default.
• W2529842825 modified "2023-09-26" @default.
• W2529842825 title "A network of conserved formins, regulated by the guanine exchange factor EXC-5/FGD and the GTPase Cdc42, modulates tubulogenesis <i>in vivo</i>" @default.
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• W2529842825 doi "https://doi.org/10.1242/dev.141861" @default.
• W2529842825 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5117219" @default.
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• W2529842825 hasPublicationYear "2016" @default.
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