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- W2529926810 abstract "Abstract Triple-negative (TN) breast cancers (ER − PR − HER2 − ) are highly metastatic and associated with poor prognosis. Within this subtype, invasive, stroma-rich tumours with infiltration of inflammatory cells are even more aggressive. The effect of myeloid cells on reactive stroma formation in TN breast cancer is largely unknown. Here, we show that primary human monocytes have a survival advantage, proliferate in vivo and develop into immunosuppressive myeloid cells expressing the myeloid-derived suppressor cell marker S100A9 only in a TN breast cancer environment. This results in activation of cancer-associated fibroblasts and expression of CXCL16, which we show to be a monocyte chemoattractant. We propose that this migratory feedback loop amplifies the formation of a reactive stroma, contributing to the aggressive phenotype of TN breast tumours. These insights could help select more suitable therapies targeting the stromal component of these tumours, and could aid prediction of drug resistance." @default.
- W2529926810 created "2016-10-21" @default.
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- W2529926810 date "2016-10-11" @default.
- W2529926810 modified "2023-10-05" @default.
- W2529926810 title "Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers" @default.
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- W2529926810 doi "https://doi.org/10.1038/ncomms13050" @default.
- W2529926810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5062608" @default.
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