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- W2529996934 abstract "Single-target single-drug paradigms have long dominated the drug discovery and development landscape. While preferential drug specificity towards a target is effective against diseases that are monogenic, the administration of single-drugs has been less successful against the widely prevalent diseases affecting large population groups like cancer, cardiovascular diseases, metabolic syndromes and neurological disorders. The majority of these complex diseases are multifactorial and are modulated by genetics, environment, age and sometimes, gender. Although drug combinations directed against two or more targets are widely employed in treatment of some diseases, the polypharmacology of marketed drugs or of new molecular entities is the new emerging paradigm for the targeting multifactorial complex diseases." @default.
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- W2529996934 date "2017-01-01" @default.
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- W2529996934 title "Holistic Drug Targeting" @default.
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- W2529996934 doi "https://doi.org/10.1016/b978-0-12-801814-9.00003-9" @default.
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