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• W2530010687 abstract "Background: Transcranial magnetic stimulation (TMS) has become an important experimental tool for exploring the brain’s functional anatomy. As TMS interferes with neural activity, the hypothetical function of the stimulated area can thus be tested. One unresolved methodological issue in TMS experiments is the question of how to adequately calibrate stimulation intensities. The motor threshold (MT) is often taken as a reference for individually adapted stimulation intensities in TMS experiments, even if they do not involve the motor system. The aim of the present study was to evaluate whether it is reasonable to adjust stimulation intensities in each subject to the individual MT if prefrontal regions are stimulated prior to the performance of a cognitive paradigm. Methods and Findings: Repetitive TMS (rTMS) was applied prior to a working memory task, either at the ‘fixed’ intensity of 40% maximum stimulator output (MSO), or individually adapted at 90% of the subject’s MT. Stimulation was applied to a target region in the left posterior middle frontal gyrus (pMFG), as indicated by a functional magnetic resonance imaging (fMRI) localizer acquired beforehand, or to a control site (vertex). Results show that MT predicted the effect size after stimulating subjects with the fixed intensity (i.e., subjects with a low MT showed a greater behavioral effect). Nevertheless, the individual adaptation of intensities did not lead to stable effects. Conclusion: Therefore, we suggest assessing MT and account for it as a measure for general cortical TMS susceptibility, even if TMS is applied outside the motor domain. Citation: Kaminski JA, Korb FM, Villringer A, Ott DVM (2011) Transcranial Magnetic Stimulation Intensities in Cognitive Paradigms. PLoS ONE 6(9): e24836. doi:10.1371/journal.pone.0024836 Editor: Joseph Najbauer, City of Hope National Medical Center and Beckman Research Institute, United States of America Received April 20, 2011; Accepted August 22, 2011; Published September 29, 2011 Copyright: 2011 Kaminski et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This research was funded by the Max Planck Institute for Human Cognitive and Brain Sciences. JAK’s work was additionally supported with two travel grants from the German National Academic Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. * E-mail: ottd@cbs.mpg.de . These authors contributed equally to this work." @default.
• W2530010687 created "2016-10-21" @default.
• W2530010687 creator A5063152300 @default.
• W2530010687 date "2015-04-09" @default.
• W2530010687 modified "2023-09-23" @default.
• W2530010687 title "Stimulationsintensitäten in kognitiven Paradigmen" @default.
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