FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2530061312> ?p ?o ?g. }

• W2530061312 endingPage "e0164706" @default.
• W2530061312 startingPage "e0164706" @default.
• W2530061312 abstract "Obesity is one of the dramatic health issues affecting developed and developing nations, and exercise is a well-established intervention strategy. While exercise-by-genotype interactions have been shown in humans, overall little is known. Using the natural negative geotaxis of Drosophila melanogaster, an important model organism for the study of genetic interactions, a novel exercise machine, the TreadWheel, can be used to shed light on this interaction. The mechanism for inducing exercise with the TreadWheel is inherently gentle, thus minimizing possible confounding effects of other stressors. Using this machine, we were able to assess large cohorts of adult flies from eight genetic lines for their response to exercise after one week of training. We measured their triglyceride, glycerol, protein, glycogen, glucose content, and body weight, as well as their climbing ability and feeding behavior in response to exercise. Exercised flies showed decreased stored triglycerides, glycogen, and body weight, and increased stored protein and climbing ability. In addition to demonstrating an overall effect of TreadWheel exercise on flies, we found significant interactions of exercise with genotype, sex, or genotype-by-sex effects for most of the measured phenotypes. We also observed interaction effects between exercise, genotype, and tissue (abdomen or thorax) for metabolite profiles, and those differences can be partially linked to innate differences in the flies' persistence in maintaining activity during exercise bouts. In addition, we assessed gene expression levels for a panel of 13 genes known to be associated with respiratory fitness and found that many responded to exercise. With this study, we have established the TreadWheel as a useful tool to study the effect of exercise in flies, shown significant genotype-specific and sex-specific impacts of exercise, and have laid the ground work for more extensive studies of how genetics, sex, environment, and aging interact with exercise to influence metabolic fitness in Drosophila." @default.
• W2530061312 created "2016-10-21" @default.
• W2530061312 creator A5001575418 @default.
• W2530061312 creator A5012388007 @default.
• W2530061312 creator A5015710077 @default.
• W2530061312 creator A5016992389 @default.
• W2530061312 creator A5021641432 @default.
• W2530061312 creator A5026099060 @default.
• W2530061312 creator A5031255909 @default.
• W2530061312 creator A5054176539 @default.
• W2530061312 date "2016-10-13" @default.
• W2530061312 modified "2023-09-27" @default.
• W2530061312 title "The TreadWheel: A Novel Apparatus to Measure Genetic Variation in Response to Gently Induced Exercise for Drosophila" @default.
• W2530061312 cites W1483949175 @default.
• W2530061312 cites W1495938445 @default.
• W2530061312 cites W1565179470 @default.
• W2530061312 cites W1749072204 @default.
• W2530061312 cites W1775749144 @default.
• W2530061312 cites W1777831458 @default.
• W2530061312 cites W1819002321 @default.
• W2530061312 cites W1819223855 @default.
• W2530061312 cites W1868630228 @default.
• W2530061312 cites W1911955076 @default.
• W2530061312 cites W1942723617 @default.
• W2530061312 cites W1968024017 @default.
• W2530061312 cites W1987307635 @default.
• W2530061312 cites W1991206627 @default.
• W2530061312 cites W2001658179 @default.
• W2530061312 cites W2001681532 @default.
• W2530061312 cites W2023724195 @default.
• W2530061312 cites W2025597850 @default.
• W2530061312 cites W2027982572 @default.
• W2530061312 cites W2033196997 @default.
• W2530061312 cites W2046746813 @default.
• W2530061312 cites W2048090832 @default.
• W2530061312 cites W2063247785 @default.
• W2530061312 cites W2077717792 @default.
• W2530061312 cites W2079867707 @default.
• W2530061312 cites W2083068465 @default.
• W2530061312 cites W2088287649 @default.
• W2530061312 cites W2102907886 @default.
• W2530061312 cites W2107520997 @default.
• W2530061312 cites W2117449982 @default.
• W2530061312 cites W2117925179 @default.
• W2530061312 cites W2119148734 @default.
• W2530061312 cites W2128635872 @default.
• W2530061312 cites W2131543898 @default.
• W2530061312 cites W2135019055 @default.
• W2530061312 cites W2135645000 @default.
• W2530061312 cites W2137609684 @default.
• W2530061312 cites W2138122607 @default.
• W2530061312 cites W2145837572 @default.
• W2530061312 cites W2151435349 @default.
• W2530061312 cites W2152832571 @default.
• W2530061312 cites W2155355896 @default.
• W2530061312 cites W2157765869 @default.
• W2530061312 cites W2159094378 @default.
• W2530061312 cites W2244276231 @default.
• W2530061312 cites W2258998699 @default.
• W2530061312 cites W2274552714 @default.
• W2530061312 cites W2329483735 @default.
• W2530061312 cites W2331756138 @default.
• W2530061312 cites W2410448823 @default.
• W2530061312 cites W3025691921 @default.
• W2530061312 cites W3123098616 @default.
• W2530061312 cites W400213307 @default.
• W2530061312 cites W4293247451 @default.
• W2530061312 doi "https://doi.org/10.1371/journal.pone.0164706" @default.
• W2530061312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5063428" @default.
• W2530061312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27736996" @default.
• W2530061312 hasPublicationYear "2016" @default.
• W2530061312 type Work @default.
• W2530061312 sameAs 2530061312 @default.
• W2530061312 citedByCount "38" @default.
• W2530061312 countsByYear W25300613122017 @default.
• W2530061312 countsByYear W25300613122018 @default.
• W2530061312 countsByYear W25300613122019 @default.
• W2530061312 countsByYear W25300613122020 @default.
• W2530061312 countsByYear W25300613122021 @default.
• W2530061312 countsByYear W25300613122022 @default.
• W2530061312 countsByYear W25300613122023 @default.
• W2530061312 crossrefType "journal-article" @default.
• W2530061312 hasAuthorship W2530061312A5001575418 @default.
• W2530061312 hasAuthorship W2530061312A5012388007 @default.
• W2530061312 hasAuthorship W2530061312A5015710077 @default.
• W2530061312 hasAuthorship W2530061312A5016992389 @default.
• W2530061312 hasAuthorship W2530061312A5021641432 @default.
• W2530061312 hasAuthorship W2530061312A5026099060 @default.
• W2530061312 hasAuthorship W2530061312A5031255909 @default.
• W2530061312 hasAuthorship W2530061312A5054176539 @default.
• W2530061312 hasBestOaLocation W25300613121 @default.
• W2530061312 hasConcept C104317684 @default.
• W2530061312 hasConcept C134018914 @default.
• W2530061312 hasConcept C135763542 @default.
• W2530061312 hasConcept C18903297 @default.
• W2530061312 hasConcept C2776041557 @default.
• W2530061312 hasConcept C2777499176 @default.
• W2530061312 hasConcept C2780104201 @default.

• next