FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2530076247> ?p ?o ?g. }

• W2530076247 endingPage "449" @default.
• W2530076247 startingPage "433" @default.
• W2530076247 abstract "Bi-allelic inactivation of SWI/SNF related, matrix-associated, actin-dependent regulator of chromatin, subfamily B member 1 (SMARCB1; also known as INI1) and loss of immunohistochemical expression of SMARCB1 define the group of SMARCB1-deficient tumours. Initially highlighted in malignant rhabdoid tumours, this inactivation has subsequently been observed in several intra and extracranial tumours. To date, primary meningeal SMARCB1-deficient tumours have not been described. We report two cases of meningeal SMARCB1-deficient tumours occurring in adults.We performed immunohistochemical analyses, comparative genomic hybridization, fluorescence in situ hybridization and targeted next-generation sequencing.The first meningeal tumour was a solitary mass, composed of rhabdoid, adenoid, chordoid and sarcomatoid areas. The second case presented as multiple, bilateral, supra and infratentorial nodules, was composed of fusiform and ovoid cells embedded in a myxoid stroma. Tumour cells were positive for epithelial membrane antigen (EMA), vimentin and CD34 and negative for SMARCB1 and meningothelial, melanocytic, muscular, glial markers. In the first case, one allele of SMARCB1 was completely deleted, whereas in the second case, loss of expression of SMARCB1 was observed as a consequence of a homozygous deletion of SMARCB1.The phenotype and genotype of these two cases did not fit diagnostically with entities already known to be SMARCB1-deficient tumours. As both tumours shared common features, they are regarded as belonging to an emerging group of primary meningeal SMARCB1-deficient tumours, not described to date. To facilitate the identification and characterization of these tumours, we recommend SMARCB1 immunohistochemistry for primary meningeal tumours which are difficult to classify, especially if immunopositive for EMA and CD34." @default.
• W2530076247 created "2016-10-21" @default.
• W2530076247 creator A5001806623 @default.
• W2530076247 creator A5003546741 @default.
• W2530076247 creator A5004466761 @default.
• W2530076247 creator A5005804337 @default.
• W2530076247 creator A5008663777 @default.
• W2530076247 creator A5011162440 @default.
• W2530076247 creator A5016607425 @default.
• W2530076247 creator A5019397737 @default.
• W2530076247 creator A5020559697 @default.
• W2530076247 creator A5041838173 @default.
• W2530076247 creator A5050474983 @default.
• W2530076247 creator A5053286003 @default.
• W2530076247 creator A5056138062 @default.
• W2530076247 creator A5077011745 @default.
• W2530076247 creator A5083225766 @default.
• W2530076247 creator A5086485115 @default.
• W2530076247 creator A5086602483 @default.
• W2530076247 creator A5087907084 @default.
• W2530076247 date "2016-12-28" @default.
• W2530076247 modified "2023-10-18" @default.
• W2530076247 title "Meningeal SWI/SNF related, matrix‐associated, actin‐dependent regulator of chromatin, subfamily B member 1 (SMARCB1)‐deficient tumours: an emerging group of meningeal tumours" @default.
• W2530076247 cites W1491398520 @default.
• W2530076247 cites W1519605175 @default.
• W2530076247 cites W1925799711 @default.
• W2530076247 cites W1965172944 @default.
• W2530076247 cites W1974984266 @default.
• W2530076247 cites W1986496248 @default.
• W2530076247 cites W1988634052 @default.
• W2530076247 cites W1989254520 @default.
• W2530076247 cites W1989700024 @default.
• W2530076247 cites W1996025229 @default.
• W2530076247 cites W2004473846 @default.
• W2530076247 cites W2006081564 @default.
• W2530076247 cites W2008105436 @default.
• W2530076247 cites W2011437246 @default.
• W2530076247 cites W2013583736 @default.
• W2530076247 cites W2014275733 @default.
• W2530076247 cites W2020197326 @default.
• W2530076247 cites W2021531214 @default.
• W2530076247 cites W2022093187 @default.
• W2530076247 cites W2022306295 @default.
• W2530076247 cites W2027858937 @default.
• W2530076247 cites W2028257398 @default.
• W2530076247 cites W2035615982 @default.
• W2530076247 cites W2039586272 @default.
• W2530076247 cites W2041489160 @default.
• W2530076247 cites W2042962536 @default.
• W2530076247 cites W2055279984 @default.
• W2530076247 cites W2056305642 @default.
• W2530076247 cites W2066752979 @default.
• W2530076247 cites W2083363149 @default.
• W2530076247 cites W2092951725 @default.
• W2530076247 cites W2094218875 @default.
• W2530076247 cites W2097619129 @default.
• W2530076247 cites W2098440387 @default.
• W2530076247 cites W2098738823 @default.
• W2530076247 cites W2101127328 @default.
• W2530076247 cites W2104570606 @default.
• W2530076247 cites W2112438623 @default.
• W2530076247 cites W2116737402 @default.
• W2530076247 cites W2117180730 @default.
• W2530076247 cites W2121262937 @default.
• W2530076247 cites W2133083689 @default.
• W2530076247 cites W2133647396 @default.
• W2530076247 cites W2141991853 @default.
• W2530076247 cites W2144379093 @default.
• W2530076247 cites W2144793849 @default.
• W2530076247 cites W2149430674 @default.
• W2530076247 cites W2154170543 @default.
• W2530076247 cites W2160273279 @default.
• W2530076247 cites W2252793495 @default.
• W2530076247 cites W4293529598 @default.
• W2530076247 doi "https://doi.org/10.1111/nan.12364" @default.
• W2530076247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27732747" @default.
• W2530076247 hasPublicationYear "2016" @default.
• W2530076247 type Work @default.
• W2530076247 sameAs 2530076247 @default.
• W2530076247 citedByCount "9" @default.
• W2530076247 countsByYear W25300762472018 @default.
• W2530076247 countsByYear W25300762472019 @default.
• W2530076247 countsByYear W25300762472020 @default.
• W2530076247 countsByYear W25300762472021 @default.
• W2530076247 crossrefType "journal-article" @default.
• W2530076247 hasAuthorship W2530076247A5001806623 @default.
• W2530076247 hasAuthorship W2530076247A5003546741 @default.
• W2530076247 hasAuthorship W2530076247A5004466761 @default.
• W2530076247 hasAuthorship W2530076247A5005804337 @default.
• W2530076247 hasAuthorship W2530076247A5008663777 @default.
• W2530076247 hasAuthorship W2530076247A5011162440 @default.
• W2530076247 hasAuthorship W2530076247A5016607425 @default.
• W2530076247 hasAuthorship W2530076247A5019397737 @default.
• W2530076247 hasAuthorship W2530076247A5020559697 @default.
• W2530076247 hasAuthorship W2530076247A5041838173 @default.
• W2530076247 hasAuthorship W2530076247A5050474983 @default.
• W2530076247 hasAuthorship W2530076247A5053286003 @default.
• W2530076247 hasAuthorship W2530076247A5056138062 @default.

• next