FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2530138053> ?p ?o ?g. }

• W2530138053 abstract "Acute kidney injury (AKI) caused by drug and toxicant ingestion is a serious clinical condition associated with high mortality rates. We currently lack detailed knowledge of the underlying molecular mechanisms and biological networks associated with AKI. In this study, we carried out gene co-expression analyses using DrugMatrix—a large toxicogenomics database with gene expression data from rats exposed to diverse chemicals—and identified gene modules associated with kidney injury to probe the molecular-level details of this disease. We generated a comprehensive set of gene co-expression modules by using the Iterative Signature Algorithm and found distinct clusters of modules that shared genes and were associated with similar chemical exposure conditions. We identified two module clusters that showed specificity for kidney injury in that they 1) were activated by chemical exposures causing kidney injury, 2) were not activated by other chemical exposures, and 3) contained known AKI-relevant genes such as Havcr1, Clu, and Tff3. We used the genes in these AKI-relevant module clusters to develop a signature of 30 genes that could assess the potential of a chemical to cause kidney injury well before injury actually occurs. We integrated AKI-relevant module cluster genes with protein-protein interaction networks and identified the involvement of immunoproteasomes in AKI. To identify biological networks and processes linked to Havcr1, we determined genes within the modules that frequently co-express with Havcr1, including Cd44, Plk2, Mdm2, Hnmt, Macrod1, and Gtpbp4. We verified this procedure by showing that randomized data did not identify Havcr1 co-expression genes and that excluding up to 10 % of the data caused only minimal degradation of the gene set. Finally, by using an external dataset from a rat kidney ischemic study, we showed that the frequently co-expressed genes of Havcr1 behaved similarly in a model of non-chemically induced kidney injury. Our study demonstrated that co-expression modules and co-expressed genes contain rich information for generating novel biomarker hypotheses and constructing mechanism-based molecular networks associated with kidney injury." @default.
• W2530138053 created "2016-10-21" @default.
• W2530138053 creator A5022862751 @default.
• W2530138053 creator A5030271505 @default.
• W2530138053 creator A5072687482 @default.
• W2530138053 creator A5090989884 @default.
• W2530138053 date "2016-10-10" @default.
• W2530138053 modified "2023-10-10" @default.
• W2530138053 title "Mining kidney toxicogenomic data by using gene co-expression modules" @default.
• W2530138053 cites W1499386625 @default.
• W2530138053 cites W1520600851 @default.
• W2530138053 cites W1600560134 @default.
• W2530138053 cites W1823837540 @default.
• W2530138053 cites W1849485327 @default.
• W2530138053 cites W1964371038 @default.
• W2530138053 cites W1965364279 @default.
• W2530138053 cites W1968129391 @default.
• W2530138053 cites W1969300589 @default.
• W2530138053 cites W1969353942 @default.
• W2530138053 cites W1970454678 @default.
• W2530138053 cites W1972498265 @default.
• W2530138053 cites W1974554585 @default.
• W2530138053 cites W1975476831 @default.
• W2530138053 cites W1979090219 @default.
• W2530138053 cites W1983617899 @default.
• W2530138053 cites W1985069389 @default.
• W2530138053 cites W1987869189 @default.
• W2530138053 cites W1989925225 @default.
• W2530138053 cites W1993445335 @default.
• W2530138053 cites W1994666901 @default.
• W2530138053 cites W1994905343 @default.
• W2530138053 cites W2000728678 @default.
• W2530138053 cites W2003418600 @default.
• W2530138053 cites W2008679807 @default.
• W2530138053 cites W2016434952 @default.
• W2530138053 cites W2019486380 @default.
• W2530138053 cites W2021041146 @default.
• W2530138053 cites W2021165859 @default.
• W2530138053 cites W2021441137 @default.
• W2530138053 cites W2021988356 @default.
• W2530138053 cites W2035618305 @default.
• W2530138053 cites W2037294334 @default.
• W2530138053 cites W2041929136 @default.
• W2530138053 cites W2042318767 @default.
• W2530138053 cites W2045949302 @default.
• W2530138053 cites W2057616292 @default.
• W2530138053 cites W2059990804 @default.
• W2530138053 cites W2060747324 @default.
• W2530138053 cites W2068928497 @default.
• W2530138053 cites W2073625832 @default.
• W2530138053 cites W2077291760 @default.
• W2530138053 cites W2077878598 @default.
• W2530138053 cites W2078326860 @default.
• W2530138053 cites W2079335697 @default.
• W2530138053 cites W2080278541 @default.
• W2530138053 cites W2081356983 @default.
• W2530138053 cites W2082252308 @default.
• W2530138053 cites W2082674299 @default.
• W2530138053 cites W2087664337 @default.
• W2530138053 cites W2091374137 @default.
• W2530138053 cites W2094022494 @default.
• W2530138053 cites W2095046428 @default.
• W2530138053 cites W2096169903 @default.
• W2530138053 cites W2099375198 @default.
• W2530138053 cites W2100025044 @default.
• W2530138053 cites W2101792171 @default.
• W2530138053 cites W2102668230 @default.
• W2530138053 cites W2107538404 @default.
• W2530138053 cites W2107628049 @default.
• W2530138053 cites W2107742731 @default.
• W2530138053 cites W2107956883 @default.
• W2530138053 cites W2108352961 @default.
• W2530138053 cites W2108491835 @default.
• W2530138053 cites W2108558127 @default.
• W2530138053 cites W2113743289 @default.
• W2530138053 cites W2114427480 @default.
• W2530138053 cites W2114702809 @default.
• W2530138053 cites W2114858095 @default.
• W2530138053 cites W2116634113 @default.
• W2530138053 cites W2117639016 @default.
• W2530138053 cites W2117724115 @default.
• W2530138053 cites W2122274181 @default.
• W2530138053 cites W2122889774 @default.
• W2530138053 cites W2123454534 @default.
• W2530138053 cites W2124001239 @default.
• W2530138053 cites W2131822674 @default.
• W2530138053 cites W2136188768 @default.
• W2530138053 cites W2136850043 @default.
• W2530138053 cites W2137272991 @default.
• W2530138053 cites W2138461176 @default.
• W2530138053 cites W2139939475 @default.
• W2530138053 cites W2140405760 @default.
• W2530138053 cites W2143224451 @default.
• W2530138053 cites W2143274936 @default.
• W2530138053 cites W2144656637 @default.
• W2530138053 cites W2145126338 @default.
• W2530138053 cites W2145307509 @default.
• W2530138053 cites W2146151086 @default.
• W2530138053 cites W2146942628 @default.
• W2530138053 cites W2148152947 @default.

• next