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- W2530151616 abstract "Objective To study the relationship between proteoglycan inhibition and the implantation of salivary pleomorphic adenoma (SPA). Methods SPA fresh tissue was primitively cultured and identified. The Ad‐shRNA‐XT‐II adenovirus vector was constructed and transfected into SPA cells to silence the XT‐II gene. The expression of the XT‐II gene and protein was detected using real‐time PCR and Western blotting, respectively. The proteoglycan content of the cells was determined 48 h after transfection. The invasion and migration of SPA cells were observed using Matrigel invasion and wound‐healing assays. Fibroblasts from the tumour capsule of the same patient were obtained, cultured and seeded onto an acellular dermal matrix (ADM) scaffold. Tumour cells were seeded onto the scaffold with the fibroblasts and then transferred to BALB/C‐nu nude mice and allowed to grow in vivo for 3 months. Results The SPA cells cultures were positive for human calponin, S‐100 protein, α‐SMA and CK. XT‐II gene and protein expression was decreased by 42.72% and 34%, respectively. The proteoglycan content was downregulated by 41.15%. XT‐II gene silencing decreased the invasion and migration abilities of SPA cells. The assessment of SPA growth in nude mice indicated an absence of tumour growth in the SPA‐XT‐II group (in which the XT‐II gene was silenced), whereas SPA growth was observed in the other two groups (in which the XT‐II gene was not silenced), and the tumour tissue was positive for the human S‐100 protein, α‐SMA and CK8&18. Conclusion Proteoglycan inhibition induced via XT‐II gene silencing inhibited the implantation of SPA." @default.
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- W2530151616 date "2016-11-17" @default.
- W2530151616 modified "2023-10-12" @default.
- W2530151616 title "The relationship between proteoglycan inhibition via xylosyltransferase II silencing and the implantation of salivary pleomorphic adenoma" @default.
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- W2530151616 doi "https://doi.org/10.1111/jop.12510" @default.
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