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• W2530156667 abstract "A major demand on immunotherapy is the direct interference with specific immune cells in vivo. In contrast to antibody-engineered nanoparticles to control dendritic cells function, targeting of T cells for biomedical applications still remains an obstacle as they disclose reduced endocytic activities. Here, by coupling the cytokine interleukin-2 (IL-2) to the surface of hydroxyethyl starch nanocapsules, we demonstrated a direct and specifc T cell targeting in vitro and in vivo by IL-2 receptor-mediated internalization. For this purpose, defined amounts of azide-functionalized IL-2 were linked to alkyne-functionalized hydroxyethyl starch nanocapsules via copper-free click reactions. In combination with validated quantification of the surface-linked IL-2 with anthracen azide, this method allowed for engineering IL-2-functionalized nanocapsules for an efficient targeting of human and murine T cell populations with various IL-2 receptor affinities. This nanocapsule-mediated technique is a promising strategy for T cell-based immunotherapies and may be translated to other cytokine-related targeting systems." @default.
• W2530156667 created "2016-10-21" @default.
• W2530156667 creator A5034838011 @default.
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• W2530156667 date "2016-10-12" @default.
• W2530156667 modified "2023-10-13" @default.
• W2530156667 title "Interleukin-2 Functionalized Nanocapsules for T Cell-Based Immunotherapy" @default.
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• W2530156667 doi "https://doi.org/10.1021/acsnano.5b07973" @default.
• W2530156667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27723299" @default.
• W2530156667 hasPublicationYear "2016" @default.
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