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• W2530276947 abstract "A series of novel 1,2,3-triazole-linked isosteviol derivatives were designed and synthesized via Huisgen-click reaction. Their cytotoxicities in vitro against HCT-116 and JEKO-1 cells were screened. The preliminary bioassays indicated that most of the title compounds exhibited noteworthy cytotoxic activities. Particularly, the compound 10b revealed the most potent inhibitory activities against HCT-116 cells with IC50 value of 2.987 ± 0.098 μM, which was better than that (3.906 ± 0.261 μM) of positive control cisplatin. On the basis of these bioactivity data, hologram quantitative structure–activity relationship (HQSAR) was performed, and a statistically reliable model with good predictive power (r2 = 0.848, q2 = 0.544 and R2pred = 0.982) was achieved. Additionally, the contribution maps derived from the optimal model explained the individual atomic contributions to the activity for each molecule." @default.
• W2530276947 created "2016-10-21" @default.
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• W2530276947 date "2016-11-01" @default.
• W2530276947 modified "2023-10-17" @default.
• W2530276947 title "Syntheses, cytotoxic activity evaluation and HQSAR study of 1,2,3-triazole-linked isosteviol derivatives as potential anticancer agents" @default.
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• W2530276947 doi "https://doi.org/10.1016/j.bmcl.2016.10.028" @default.
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