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• W2530311943 startingPage "185" @default.
• W2530311943 abstract "Altered glutamate neurotransmission is implicated in the etiology of schizophrenia (SCZ) and the pharmacogenetics of response to clozapine (CLZ), which is the drug of choice for treatment-resistant SCZ. Response to antipsychotic therapy is highly variable, although twin studies suggest a genetic component. We investigated the association of 10 glutamate system gene variants with CLZ response using standard genotyping procedures. <i>GRM2</i> (rs4067 and rs2518461), <i>SLC1A2</i> (rs4354668, rs4534557, and rs2901534), <i>SLC6A9</i> (rs12037805, rs1978195, and rs16831558), <i>GRIA1</i> (rs2195450), and <i>GAD1</i> (rs3749034) were typed in 163 European SCZ/schizoaffective disorder patients deemed resistant or intolerant to previous pharmacotherapy. Response was assessed following 6 months of CLZ monotherapy using change in Brief Psychiatric Rating Scale (BPRS) scores. Categorical and continuous response variables were analyzed using &#x03C7;² tests and analysis of covariance, respectively. We report no significant associations following correction for multiple testing. Prior to correction, nominally significant associations were observed for <i>SLC6A9</i>, <i>SLC1A2</i>, <i>GRM2</i>, and <i>GRIA1</i>. Most notably, CC homozygotes of rs16831558 located in the glycine transporter 1 gene <i>(SLC6A9)</i> exhibited an allele dose-dependent improvement in positive symptoms compared to T allele carriers (p_uncorrected = 0.008, p_corrected = 0.08). To clarify the role of <i>SLC6A9</i> in clinical response to antipsychotic medication, and CLZ in particular, this finding warrants further investigation in larger well-characterized samples." @default.
• W2530311943 created "2016-10-21" @default.
• W2530311943 creator A5022065571 @default.
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• W2530311943 date "2016-01-01" @default.
• W2530311943 modified "2023-10-02" @default.
• W2530311943 title "Pharmacogenetic Analysis of Functional Glutamate System Gene Variants and Clinical Response to Clozapine" @default.
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• W2530311943 doi "https://doi.org/10.1159/000449224" @default.
• W2530311943 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5318922" @default.

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