Matches in SemOpenAlex for { <https://semopenalex.org/work/W2530341743> ?p ?o ?g. }
- W2530341743 endingPage "1689" @default.
- W2530341743 startingPage "1689" @default.
- W2530341743 abstract "The incidence of obesity and its comorbidities, such as insulin resistance and type II diabetes, are increasing dramatically, perhaps caused by the change in the fatty acid composition of common human diets. Adipose tissue plays a role as the major energy reservoir in the body. An excess of adipose mass accumulation caused by chronic positive energy balance results in obesity. The n-3 polyunsaturated fatty acids (n-3 PUFA), DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid) exert numerous beneficial effects to maintain physiological homeostasis. In the current review, the physiology of n-3 PUFA effects in the body is delineated from studies conducted in both human and animal experiments. Although mechanistic studies in human are limited, numerous studies conducted in animals and models in vitro provide potential molecular mechanisms of the effects of these fatty acids. Three aspects of n-3 PUFA in adipocyte regulation are discussed: (1) lipid metabolism, including adipocyte differentiation, lipolysis and lipogenesis; (2) energy expenditure, such as mitochondrial and peroxisomal fatty acid β-oxidation; and (3) inflammation, including adipokines and specialized pro-resolving lipid mediators. Additionally, the mechanisms by which n-3 PUFA regulate gene expression are highlighted. The beneficial effects of n-3 PUFA may help to reduce the incidence of obesity and its comorbidities." @default.
- W2530341743 created "2016-10-21" @default.
- W2530341743 creator A5006332584 @default.
- W2530341743 creator A5032427357 @default.
- W2530341743 creator A5034832846 @default.
- W2530341743 creator A5051082988 @default.
- W2530341743 creator A5064655192 @default.
- W2530341743 creator A5066066922 @default.
- W2530341743 date "2016-10-09" @default.
- W2530341743 modified "2023-10-05" @default.
- W2530341743 title "Role of n-3 Polyunsaturated Fatty Acids in Ameliorating the Obesity-Induced Metabolic Syndrome in Animal Models and Humans" @default.
- W2530341743 cites W1511998280 @default.
- W2530341743 cites W1515671273 @default.
- W2530341743 cites W1550221649 @default.
- W2530341743 cites W1553522390 @default.
- W2530341743 cites W1571968593 @default.
- W2530341743 cites W1582691127 @default.
- W2530341743 cites W1591032344 @default.
- W2530341743 cites W1593931056 @default.
- W2530341743 cites W1648382494 @default.
- W2530341743 cites W1725128160 @default.
- W2530341743 cites W1778645648 @default.
- W2530341743 cites W1834303186 @default.
- W2530341743 cites W1850077490 @default.
- W2530341743 cites W1863611356 @default.
- W2530341743 cites W1871392051 @default.
- W2530341743 cites W1889359478 @default.
- W2530341743 cites W1902862013 @default.
- W2530341743 cites W1911154327 @default.
- W2530341743 cites W1919042563 @default.
- W2530341743 cites W1924593494 @default.
- W2530341743 cites W1929380714 @default.
- W2530341743 cites W1937005209 @default.
- W2530341743 cites W1953076578 @default.
- W2530341743 cites W1955580249 @default.
- W2530341743 cites W1965039157 @default.
- W2530341743 cites W1965079305 @default.
- W2530341743 cites W1966136261 @default.
- W2530341743 cites W1966887410 @default.
- W2530341743 cites W1969293522 @default.
- W2530341743 cites W1974186154 @default.
- W2530341743 cites W1974235694 @default.
- W2530341743 cites W1974239762 @default.
- W2530341743 cites W1976379973 @default.
- W2530341743 cites W1979026577 @default.
- W2530341743 cites W1980825557 @default.
- W2530341743 cites W1981091569 @default.
- W2530341743 cites W1981101682 @default.
- W2530341743 cites W1982178416 @default.
- W2530341743 cites W1982342677 @default.
- W2530341743 cites W1985461968 @default.
- W2530341743 cites W1987335225 @default.
- W2530341743 cites W1989020172 @default.
- W2530341743 cites W1989835057 @default.
- W2530341743 cites W1991334358 @default.
- W2530341743 cites W1992124625 @default.
- W2530341743 cites W1994356018 @default.
- W2530341743 cites W1996063029 @default.
- W2530341743 cites W1997248234 @default.
- W2530341743 cites W1997504056 @default.
- W2530341743 cites W1998098109 @default.
- W2530341743 cites W1999986580 @default.
- W2530341743 cites W2000011436 @default.
- W2530341743 cites W2000054651 @default.
- W2530341743 cites W2000849147 @default.
- W2530341743 cites W2001513552 @default.
- W2530341743 cites W2001956548 @default.
- W2530341743 cites W2003178124 @default.
- W2530341743 cites W2003347868 @default.
- W2530341743 cites W2005390270 @default.
- W2530341743 cites W2005827500 @default.
- W2530341743 cites W2006251119 @default.
- W2530341743 cites W2006862294 @default.
- W2530341743 cites W2007496314 @default.
- W2530341743 cites W2008150005 @default.
- W2530341743 cites W2008869160 @default.
- W2530341743 cites W2012577411 @default.
- W2530341743 cites W2013071753 @default.
- W2530341743 cites W201823729 @default.
- W2530341743 cites W2019197047 @default.
- W2530341743 cites W2020275122 @default.
- W2530341743 cites W2020956542 @default.
- W2530341743 cites W2022683252 @default.
- W2530341743 cites W2023006621 @default.
- W2530341743 cites W2023394218 @default.
- W2530341743 cites W2024610150 @default.
- W2530341743 cites W2027442810 @default.
- W2530341743 cites W2027753197 @default.
- W2530341743 cites W2027836112 @default.
- W2530341743 cites W2029135683 @default.
- W2530341743 cites W2033283286 @default.
- W2530341743 cites W2034816376 @default.
- W2530341743 cites W2034937725 @default.
- W2530341743 cites W2036594324 @default.
- W2530341743 cites W2040354463 @default.
- W2530341743 cites W2041272958 @default.
- W2530341743 cites W2041690929 @default.
- W2530341743 cites W2041890645 @default.