FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2530367000> ?p ?o ?g. }

• W2530367000 endingPage "4650" @default.
• W2530367000 startingPage "4643" @default.
• W2530367000 abstract "The collagen gel droplet-embedded culture drug sensitivity test (CD‑DST) is an anticancer drug sensitivity test that uses a method of three-dimensional culture of extremely small samples, and it is suited to primary cultures of human cancer cells. It is a useful method for oral squamous cell carcinoma (OSCC), in which the cancer tissues available for testing are limited. However, since the optimal contact concentrations of anticancer drugs have yet to be established in OSCC, CD‑DST for detecting drug sensitivities of OSCC is currently performed by applying the optimal contact concentrations for stomach cancer. In the present study, squamous carcinoma cell lines from human oral cancer were used to investigate the optimal contact concentrations of cisplatin (CDDP) and fluorouracil (5‑FU) during CD‑DST for OSCC. CD‑DST was performed in 7 squamous cell carcinoma cell lines derived from human oral cancers (Ca9‑22, HSC‑3, HSC‑4, HO‑1‑N‑1, KON, OSC‑19 and SAS) using CDDP (0.15, 0.3, 1.25, 2.5, 5.0 and 10.0 µg/ml) and 5‑FU (0.4, 0.9, 1.8, 3.8, 7.5, 15.0 and 30.0 µg/ml), and the optimal contact concentrations were calculated from the clinical response rate of OSCC to single‑drug treatment and the in vitro efficacy rate curve. The optimal concentrations were 0.5 µg/ml for CDDP and 0.7 µg/ml for 5‑FU. The antitumor efficacy of CDDP at this optimal contact concentration in CD‑DST was compared to the antitumor efficacy in the nude mouse method. The T/C values, which were calculated as the ratio of the colony volume of the treatment group and the colony volume of the control group, at the optimal contact concentration of CDDP and of the nude mouse method were almost in agreement (P<0.05) and predicted clinical efficacy, indicating that the calculated optimal contact concentration is valid. Therefore, chemotherapy for OSCC based on anticancer drug sensitivity tests offers patients a greater freedom of choice and is likely to assume a greater importance in the selection of treatment from the perspectives of function preservation and quality of life, as well as representing a treatment option for unresectable, intractable or recurrent cases." @default.
• W2530367000 created "2016-10-21" @default.
• W2530367000 creator A5061345986 @default.
• W2530367000 creator A5064590336 @default.
• W2530367000 creator A5071856411 @default.
• W2530367000 date "2016-10-11" @default.
• W2530367000 modified "2023-10-17" @default.
• W2530367000 title "Collagen gel droplet-embedded culture drug sensitivity testing in squamous cell carcinoma cell lines derived from human oral cancers: Optimal contact concentrations of cisplatin and fluorouracil" @default.
• W2530367000 cites W189287319 @default.
• W2530367000 cites W1965558021 @default.
• W2530367000 cites W1968741994 @default.
• W2530367000 cites W1975088494 @default.
• W2530367000 cites W1977957608 @default.
• W2530367000 cites W2001865989 @default.
• W2530367000 cites W2012809050 @default.
• W2530367000 cites W2014242130 @default.
• W2530367000 cites W2032295258 @default.
• W2530367000 cites W2034433264 @default.
• W2530367000 cites W2035280973 @default.
• W2530367000 cites W2036005555 @default.
• W2530367000 cites W2038341210 @default.
• W2530367000 cites W2040477534 @default.
• W2530367000 cites W2048393044 @default.
• W2530367000 cites W2050648887 @default.
• W2530367000 cites W2054624164 @default.
• W2530367000 cites W2077484102 @default.
• W2530367000 cites W2099082193 @default.
• W2530367000 cites W2100961085 @default.
• W2530367000 cites W2109261874 @default.
• W2530367000 cites W2126018463 @default.
• W2530367000 cites W2137234355 @default.
• W2530367000 cites W2138079449 @default.
• W2530367000 cites W2141592118 @default.
• W2530367000 cites W2146148650 @default.
• W2530367000 cites W2154914070 @default.
• W2530367000 cites W2167832147 @default.
• W2530367000 cites W2215243012 @default.
• W2530367000 cites W2288125623 @default.
• W2530367000 cites W2320302422 @default.
• W2530367000 cites W2397236059 @default.
• W2530367000 cites W2401633823 @default.
• W2530367000 cites W2406166241 @default.
• W2530367000 cites W2408034198 @default.
• W2530367000 cites W2408749229 @default.
• W2530367000 cites W2415882482 @default.
• W2530367000 cites W2418248819 @default.
• W2530367000 cites W2418679701 @default.
• W2530367000 cites W2440826530 @default.
• W2530367000 cites W2443282773 @default.
• W2530367000 cites W4317675821 @default.
• W2530367000 doi "https://doi.org/10.3892/ol.2016.5238" @default.
• W2530367000 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5228427" @default.
• W2530367000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28105171" @default.
• W2530367000 hasPublicationYear "2016" @default.
• W2530367000 type Work @default.
• W2530367000 sameAs 2530367000 @default.
• W2530367000 citedByCount "10" @default.
• W2530367000 countsByYear W25303670002017 @default.
• W2530367000 countsByYear W25303670002018 @default.
• W2530367000 countsByYear W25303670002019 @default.
• W2530367000 countsByYear W25303670002021 @default.
• W2530367000 countsByYear W25303670002023 @default.
• W2530367000 crossrefType "journal-article" @default.
• W2530367000 hasAuthorship W2530367000A5061345986 @default.
• W2530367000 hasAuthorship W2530367000A5064590336 @default.
• W2530367000 hasAuthorship W2530367000A5071856411 @default.
• W2530367000 hasBestOaLocation W25303670001 @default.
• W2530367000 hasConcept C121608353 @default.
• W2530367000 hasConcept C126322002 @default.
• W2530367000 hasConcept C142724271 @default.
• W2530367000 hasConcept C1491633281 @default.
• W2530367000 hasConcept C185592680 @default.
• W2530367000 hasConcept C2776694085 @default.
• W2530367000 hasConcept C2777546739 @default.
• W2530367000 hasConcept C2778239845 @default.
• W2530367000 hasConcept C2780035454 @default.
• W2530367000 hasConcept C2780456651 @default.
• W2530367000 hasConcept C2781018059 @default.
• W2530367000 hasConcept C29537977 @default.
• W2530367000 hasConcept C2994491419 @default.
• W2530367000 hasConcept C3019992690 @default.
• W2530367000 hasConcept C502942594 @default.
• W2530367000 hasConcept C54355233 @default.
• W2530367000 hasConcept C55493867 @default.
• W2530367000 hasConcept C67082663 @default.
• W2530367000 hasConcept C71924100 @default.
• W2530367000 hasConcept C81885089 @default.
• W2530367000 hasConcept C86803240 @default.
• W2530367000 hasConcept C96232424 @default.
• W2530367000 hasConcept C98274493 @default.
• W2530367000 hasConceptScore W2530367000C121608353 @default.
• W2530367000 hasConceptScore W2530367000C126322002 @default.
• W2530367000 hasConceptScore W2530367000C142724271 @default.
• W2530367000 hasConceptScore W2530367000C1491633281 @default.
• W2530367000 hasConceptScore W2530367000C185592680 @default.
• W2530367000 hasConceptScore W2530367000C2776694085 @default.
• W2530367000 hasConceptScore W2530367000C2777546739 @default.
• W2530367000 hasConceptScore W2530367000C2778239845 @default.

• next