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- W2530393753 abstract "m (miRNA) are small non-coding RNA molecules that regulate gene expression posttranscriptionally. miRNAs have emerged as a critical regulatory pathway in the mammalian central nervous system (CNS). By profiling the expression patterns of miRNAs in both oligodendroglial cell line and oligodendrocytes purified by FACS from the CNP-EGFP transgenic mice, we have identified 145 miRNAs expressed in oligodendrocytes. We showed that miR-20a interacts specifically with the 3’UTR of the proteolipid protein (PLP1), a major CNS myelin protein, and suppresses PLP1 expression in oligodendrocytes (Journal of Neuroscience Research, 2012, in press). In the current study, we sought to investigate the regulatory roles of miR-20a in the expression of genes that are important for either oligodendrocytic cell biology or RNA metabolism. Exogenous miR-20a precursor mimics and anti-sense inhibitors were introduced into oligodendrocytes to upand down-regulate the endogenous miR-20a production, respectively. Real-time qRT-PCR analysis was performed to monitor the changes in mRNA expression level of 12 RNA processing factors and 14 genes that are involved in transcriptional regulation or signal transduction pathways in oligodendrocytes. We show that miR-20a controls the expression of splicing regulators hnRNP H, hnRNP I, hnRNP A2B1, Tra2a, Sfrs7 and Sfrs11, transcription factors Pou6f1, Stat2 and Sox6, and protein kinases Cdk2 and Cdk5rap2. In addition, the expression of Hdac 3 and IGF-I is regulated by miR-20a. Taken together, we demonstrate for the first time that miR-20a broadly regulates genes that are involved in oligodendrocyte differentiation, splicing and PLP alternative splicing." @default.
- W2530393753 created "2016-10-21" @default.
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- W2530393753 date "2013-06-18" @default.
- W2530393753 modified "2023-09-24" @default.
- W2530393753 title "miR-20a regulates genes involved in oligodendrocyte lineage and splicing" @default.
- W2530393753 hasPublicationYear "2013" @default.
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