Matches in SemOpenAlex for { <https://semopenalex.org/work/W2530487514> ?p ?o ?g. }
- W2530487514 endingPage "1335" @default.
- W2530487514 startingPage "1326" @default.
- W2530487514 abstract "Abstract We previously reported that rice endosperm protein (REP) has renoprotective effects in Goto–Kakizaki rats, a non-obese diabetic model. However, whether these effects occur in obese diabetes remains unclear. This study aimed to clarify the effects of REP on obese diabetes, especially on fatty liver and diabetic nephropathy, using the obese diabetic model Zucker diabetic fatty (ZDF) rats. In total, 7-week-old male ZDF rats were fed diets containing 20 % REP or casein (C) for 8 weeks. Changes in fasting blood glucose levels and urinary markers were monitored during the experimental period. Hepatic lipids and metabolites were measured and renal glomeruli were observed morphologically. HbA1c levels were significantly lower in rats fed REP, compared with C ( P <0·05). Compared with C in the liver, REP prevented lipid accumulation (total lipid, TAG and total cholesterol, P <0·01). Liver metabolome analysis indicated that levels of metabolites associated with glycolysis, the pentose phosphate pathway and carnitine metabolism were significantly greater in the REP group than in the C group ( P <0·05), suggesting activation of both glucose catabolism and fatty acid oxidation. The metabolite increases promoted by REP may contribute to suppression of liver lipid accumulation. Urinary excretion of albumin and N -acetyl- β - d -glucosaminidase was significantly reduced in rats fed REP for 8 weeks ( P <0·01). In addition, there was a distinct suppression of mesangial matrix expansion and glomerular hypertrophy in response to REP ( P <0·01). Thus, REP had preventive effects on obese diabetes, fatty liver and diabetic nephropathy." @default.
- W2530487514 created "2016-10-21" @default.
- W2530487514 creator A5001988444 @default.
- W2530487514 creator A5002881989 @default.
- W2530487514 creator A5026187160 @default.
- W2530487514 creator A5050494428 @default.
- W2530487514 creator A5052031158 @default.
- W2530487514 creator A5052403672 @default.
- W2530487514 creator A5074733950 @default.
- W2530487514 creator A5087286731 @default.
- W2530487514 date "2016-10-11" @default.
- W2530487514 modified "2023-10-16" @default.
- W2530487514 title "Rice endosperm protein slows progression of fatty liver and diabetic nephropathy in Zucker diabetic fatty rats" @default.
- W2530487514 cites W1573055659 @default.
- W2530487514 cites W1775321216 @default.
- W2530487514 cites W1790103964 @default.
- W2530487514 cites W1793372331 @default.
- W2530487514 cites W1826616785 @default.
- W2530487514 cites W1831301545 @default.
- W2530487514 cites W1913947155 @default.
- W2530487514 cites W1964491791 @default.
- W2530487514 cites W1964835867 @default.
- W2530487514 cites W1966866971 @default.
- W2530487514 cites W1969656849 @default.
- W2530487514 cites W1973247310 @default.
- W2530487514 cites W1974824856 @default.
- W2530487514 cites W1976634024 @default.
- W2530487514 cites W1982610111 @default.
- W2530487514 cites W1993179499 @default.
- W2530487514 cites W2002624663 @default.
- W2530487514 cites W2014344801 @default.
- W2530487514 cites W2020965256 @default.
- W2530487514 cites W2021375967 @default.
- W2530487514 cites W2022677545 @default.
- W2530487514 cites W2023896302 @default.
- W2530487514 cites W2040692903 @default.
- W2530487514 cites W2062185293 @default.
- W2530487514 cites W2062237920 @default.
- W2530487514 cites W2075787199 @default.
- W2530487514 cites W2075882762 @default.
- W2530487514 cites W2099436039 @default.
- W2530487514 cites W2106814268 @default.
- W2530487514 cites W2113985146 @default.
- W2530487514 cites W2133773602 @default.
- W2530487514 cites W2138419214 @default.
- W2530487514 cites W2139923324 @default.
- W2530487514 cites W2140871565 @default.
- W2530487514 cites W2141385164 @default.
- W2530487514 cites W2142844314 @default.
- W2530487514 cites W2144206418 @default.
- W2530487514 cites W2145651826 @default.
- W2530487514 cites W2156606821 @default.
- W2530487514 cites W2165056208 @default.
- W2530487514 cites W2168526937 @default.
- W2530487514 cites W2170630683 @default.
- W2530487514 cites W2171541767 @default.
- W2530487514 cites W2230222215 @default.
- W2530487514 cites W2279871045 @default.
- W2530487514 cites W2319030457 @default.
- W2530487514 doi "https://doi.org/10.1017/s0007114516003512" @default.
- W2530487514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27724997" @default.
- W2530487514 hasPublicationYear "2016" @default.
- W2530487514 type Work @default.
- W2530487514 sameAs 2530487514 @default.
- W2530487514 citedByCount "18" @default.
- W2530487514 countsByYear W25304875142016 @default.
- W2530487514 countsByYear W25304875142017 @default.
- W2530487514 countsByYear W25304875142019 @default.
- W2530487514 countsByYear W25304875142020 @default.
- W2530487514 countsByYear W25304875142021 @default.
- W2530487514 countsByYear W25304875142022 @default.
- W2530487514 countsByYear W25304875142023 @default.
- W2530487514 crossrefType "journal-article" @default.
- W2530487514 hasAuthorship W2530487514A5001988444 @default.
- W2530487514 hasAuthorship W2530487514A5002881989 @default.
- W2530487514 hasAuthorship W2530487514A5026187160 @default.
- W2530487514 hasAuthorship W2530487514A5050494428 @default.
- W2530487514 hasAuthorship W2530487514A5052031158 @default.
- W2530487514 hasAuthorship W2530487514A5052403672 @default.
- W2530487514 hasAuthorship W2530487514A5074733950 @default.
- W2530487514 hasAuthorship W2530487514A5087286731 @default.
- W2530487514 hasBestOaLocation W25304875141 @default.
- W2530487514 hasConcept C126322002 @default.
- W2530487514 hasConcept C134018914 @default.
- W2530487514 hasConcept C185592680 @default.
- W2530487514 hasConcept C2778772119 @default.
- W2530487514 hasConcept C2779134260 @default.
- W2530487514 hasConcept C2779922275 @default.
- W2530487514 hasConcept C2781184683 @default.
- W2530487514 hasConcept C4733338 @default.
- W2530487514 hasConcept C555293320 @default.
- W2530487514 hasConcept C71924100 @default.
- W2530487514 hasConceptScore W2530487514C126322002 @default.
- W2530487514 hasConceptScore W2530487514C134018914 @default.
- W2530487514 hasConceptScore W2530487514C185592680 @default.
- W2530487514 hasConceptScore W2530487514C2778772119 @default.
- W2530487514 hasConceptScore W2530487514C2779134260 @default.
- W2530487514 hasConceptScore W2530487514C2779922275 @default.