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• W2530492937 startingPage "69" @default.
• W2530492937 abstract "Cell division is a complex process with high energy demands. However, how cells regulate the generation of energy required for DNA synthesis and chromosome segregation is not well understood. Recent data suggest that changes in mitochondrial dynamics and metabolic pathways such as oxidative phosphorylation (OXPHOS) and glycolysis crosstalk with, and are tightly regulated by, the cell division machinery. Alterations in energy availability trigger cell-cycle checkpoints, suggesting a bidirectional connection between cell division and general metabolism. Some of these connections are altered in human disease, and their manipulation may help in designing therapeutic strategies for specific diseases including cancer. We review here recent studies describing the control of metabolism by the cell-cycle machinery." @default.
• W2530492937 created "2016-10-21" @default.
• W2530492937 creator A5010663340 @default.
• W2530492937 creator A5042903683 @default.
• W2530492937 date "2017-01-01" @default.
• W2530492937 modified "2023-10-14" @default.
• W2530492937 title "Fueling the Cell Division Cycle" @default.
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• W2530492937 doi "https://doi.org/10.1016/j.tcb.2016.08.009" @default.
• W2530492937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27746095" @default.
• W2530492937 hasPublicationYear "2017" @default.
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