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- W2530540379 endingPage "7137" @default.
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- W2530540379 abstract "The interaction between T cells and the central nervous system (CNS) in homeostasis and injury has been recognized being both pathogenic (CD4+ T-helper 1 - Th1, Th17 and γδT) and ameliorative (Th2 and regulatory T cells - Tregs). However, in-depth studies aimed to elucidate the precise in the aged microenvironment and the dichotomous role of Tregs have just begun and many aspects remain unclear. This is due, not only to a mutual dependency and reciprocal causation of alterations and diseases between the nervous and T cell immune systems, but also to an inconsistent aging of the two systems, which dynamically changes with CNS injury/recovery and/or aging process. Cellular immune system aging, particularly immunosenescence and T cell aging initiated by thymic involution - sources of chronic inflammation in the elderly (termed inflammaging), potentially induces an acceleration of brain aging and memory loss. In turn, aging of the brain via neuro-endocrine-immune network drives total body systemic aging, including that of the immune system. Therefore, immunotherapeutics including vaccination and protective autoimmunity provide promising means to rejuvenate neuro-inflammatory disorders and repair CNS acute injury and chronic neuro-degeneration. We review the current understanding and recent discoveries linking the aging immune system with CNS injury and neuro-degeneration. Additionally, we discuss potential recovery and rejuvenation strategies, focusing on targeting the aging T cell immune system in an effort to alleviate acute brain injury and chronic neuro-degeneration during aging, via the thymus-inflammaging-neurodegeneration axis." @default.
- W2530540379 created "2016-10-21" @default.
- W2530540379 creator A5011769423 @default.
- W2530540379 creator A5034468233 @default.
- W2530540379 creator A5056369021 @default.
- W2530540379 creator A5056690952 @default.
- W2530540379 creator A5063141445 @default.
- W2530540379 creator A5085525879 @default.
- W2530540379 date "2016-10-11" @default.
- W2530540379 modified "2023-09-26" @default.
- W2530540379 title "Friend or foe: the dichotomous impact of T cells on neuro-de/re-generation during aging" @default.
- W2530540379 cites W1500603097 @default.
- W2530540379 cites W1518197089 @default.
- W2530540379 cites W1526074260 @default.
- W2530540379 cites W1529674879 @default.
- W2530540379 cites W1546232808 @default.
- W2530540379 cites W1547955534 @default.
- W2530540379 cites W1554128413 @default.
- W2530540379 cites W1554329005 @default.
- W2530540379 cites W1566509581 @default.
- W2530540379 cites W1567490604 @default.
- W2530540379 cites W1581792805 @default.
- W2530540379 cites W1582763552 @default.
- W2530540379 cites W1583123980 @default.
- W2530540379 cites W1588685142 @default.
- W2530540379 cites W1618035875 @default.
- W2530540379 cites W1720514029 @default.
- W2530540379 cites W1781054981 @default.
- W2530540379 cites W1792313443 @default.
- W2530540379 cites W1797422316 @default.
- W2530540379 cites W1817759654 @default.
- W2530540379 cites W1817869068 @default.
- W2530540379 cites W1820592927 @default.
- W2530540379 cites W1828045052 @default.
- W2530540379 cites W1841850981 @default.
- W2530540379 cites W1852100855 @default.
- W2530540379 cites W1852440647 @default.
- W2530540379 cites W1894517614 @default.
- W2530540379 cites W1926141441 @default.
- W2530540379 cites W1946941723 @default.
- W2530540379 cites W1964118321 @default.
- W2530540379 cites W1965707131 @default.
- W2530540379 cites W1965942744 @default.
- W2530540379 cites W1966909420 @default.
- W2530540379 cites W1967399741 @default.
- W2530540379 cites W1967640115 @default.
- W2530540379 cites W1968057097 @default.
- W2530540379 cites W1968863779 @default.
- W2530540379 cites W1969257664 @default.
- W2530540379 cites W1969994843 @default.
- W2530540379 cites W1970433280 @default.
- W2530540379 cites W1970606114 @default.
- W2530540379 cites W1970864084 @default.
- W2530540379 cites W1972478340 @default.
- W2530540379 cites W1973338533 @default.
- W2530540379 cites W1975782252 @default.
- W2530540379 cites W1976018161 @default.
- W2530540379 cites W1976266513 @default.
- W2530540379 cites W1976597647 @default.
- W2530540379 cites W1977213877 @default.
- W2530540379 cites W1980930214 @default.
- W2530540379 cites W1981764021 @default.
- W2530540379 cites W1983865214 @default.
- W2530540379 cites W1984576323 @default.
- W2530540379 cites W1985912156 @default.
- W2530540379 cites W1986763065 @default.
- W2530540379 cites W1987015752 @default.
- W2530540379 cites W1989734927 @default.
- W2530540379 cites W1990826584 @default.
- W2530540379 cites W1991156200 @default.
- W2530540379 cites W1991993391 @default.
- W2530540379 cites W1992139204 @default.
- W2530540379 cites W1992431343 @default.
- W2530540379 cites W1992481740 @default.
- W2530540379 cites W1993643210 @default.
- W2530540379 cites W1993976394 @default.
- W2530540379 cites W1994160001 @default.
- W2530540379 cites W1994162431 @default.
- W2530540379 cites W1994360777 @default.
- W2530540379 cites W1996024251 @default.
- W2530540379 cites W1996995902 @default.
- W2530540379 cites W1997295138 @default.
- W2530540379 cites W1999690779 @default.
- W2530540379 cites W1999903550 @default.
- W2530540379 cites W2000354382 @default.
- W2530540379 cites W2001618696 @default.
- W2530540379 cites W2001717792 @default.
- W2530540379 cites W2001720505 @default.
- W2530540379 cites W2002607039 @default.
- W2530540379 cites W2002824497 @default.
- W2530540379 cites W2006274267 @default.
- W2530540379 cites W2008862517 @default.
- W2530540379 cites W2010417927 @default.
- W2530540379 cites W2010905407 @default.
- W2530540379 cites W2012028111 @default.
- W2530540379 cites W2012174890 @default.
- W2530540379 cites W2012779930 @default.
- W2530540379 cites W2013317807 @default.