FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2530542011> ?p ?o ?g. }

• W2530542011 abstract "Abstract Background : Although considerable progress has been made in treating acute lymphoblastic leukemia (ALL) in the pediatric population, with long-term survival exceeding 80%, the prognosis for adolescents, young adult, and adult patients with ALL remains poor, with only 30%-45% of patients achieving long-term survival. Several studies suggest that young adult patients have superior overall survival when treated with intensive pediatric-inspired regimens that include the use of asparaginase [Dombret H, et al. Curr Hematol Malig Rep. 2014;9(2):158-164]. Despite these results, many young adult patients with ALL continue to be treated with chemotherapy regimens that include little or no asparaginase. The goal of this study was to assess the views and practices of hematologists and oncologists with respect to asparaginase use in young adult patients with ALL. Methods : This study was conducted between May 14 and June 22, 2015, and consisted of a 10-minute online quantitative survey, with a 10-minute per-patient chart audit component for up to 4 charts provided by participating physicians. The survey targeted physicians treating young adult patients (aged 18-40 years) with ALL. To be included in the final analysis, physicians were required to be board certified with 2-30 years in practice, with ≥75% of their time spent in direct patient care and ≥20% of their time spent in an academic setting (NCCN/NCI or academic/teaching hospital). Inclusion criteria also required that physicians' total ALL patient volume (young adults and adults aged &gt;40 years) was greater than 5 over the past 2 years, that the physician primarily treats adult patients, and has personally managed and treated at least 1 young adult ALL patient in the past 2 years. Results: The study included results reported by a total of 63 practicing physicians for 189 young adult patients with ALL (62% were aged 25-40 years). Sixty percent (114/189) of young adult patients were treated with a protocol that included asparaginase, and only 29% (55/189) on a pediatric-inspired protocol. The most common protocols reported for patients receiving asparaginase included the pediatric-inspired CALGB 10403 (18%, 21/114), as well as regimens with more limited asparaginase use, including augmented hyper-CVAD (29%, 33/114) and CALGB 8811 (12%, 14/114). Overall 40% (75/189) of young adult patients were treated with protocols that did not include asparaginase, most commonly hyper-CVAD (77%, 58/75). Fifty percent (18/36) of responding physicians using hyper-CVAD reported the perception of similar outcomes with nonasparaginase regimens as with asparaginase-intensive regimens. When questioned about the greatest barrier to the use of intensive asparaginase-containing regimens, 88% (7/8) of responding physicians reported safety and tolerability concerns. Conclusion: Only 6 out of 10 patients in the study were treated with an asparaginase-containing regimen; of all patients, less than 1 out of 3 received a pediatric-inspired regimen. Fifty-three percent (60/114) of asparaginase-receiving patients were treated on a regimen that structures asparaginase dosing intermittently between alternating courses. Pediatric-inspired regimens include intensive asparaginase therapy and have consistently shown improvements in overall survival when compared with traditional adult protocols in clinical trials [Dombret H, et al. Curr Hematol Malig Rep. 2014;9(2):158-164]. Support: This study was funded by Jazz Pharmaceuticals. Disclosures Sender: Jazz Pharmaceuticals: Research Funding, Speakers Bureau. Doede:Jazz Pharmaceuticals: Employment, Equity Ownership. Hall:Jazz Pharmaceuticals: Employment, Equity Ownership. Bernard:Jazz Pharmaceuticals: Employment, Equity Ownership." @default.
• W2530542011 created "2016-10-21" @default.
• W2530542011 creator A5026004740 @default.
• W2530542011 creator A5040884396 @default.
• W2530542011 creator A5054595403 @default.
• W2530542011 creator A5081546407 @default.
• W2530542011 date "2015-12-03" @default.
• W2530542011 modified "2023-09-27" @default.
• W2530542011 title "Intensive Asparaginase Therapy in Young Adult Patients with Acute Lymphoblastic Leukemia: Treatment Patterns and Barriers to Asparaginase Use" @default.
• W2530542011 doi "https://doi.org/10.1182/blood.v126.23.4913.4913" @default.
• W2530542011 hasPublicationYear "2015" @default.
• W2530542011 type Work @default.
• W2530542011 sameAs 2530542011 @default.
• W2530542011 citedByCount "0" @default.
• W2530542011 crossrefType "journal-article" @default.
• W2530542011 hasAuthorship W2530542011A5026004740 @default.
• W2530542011 hasAuthorship W2530542011A5040884396 @default.
• W2530542011 hasAuthorship W2530542011A5054595403 @default.
• W2530542011 hasAuthorship W2530542011A5081546407 @default.
• W2530542011 hasConcept C126322002 @default.
• W2530542011 hasConcept C187212893 @default.
• W2530542011 hasConcept C205545832 @default.
• W2530542011 hasConcept C2778461978 @default.
• W2530542011 hasConcept C2778904437 @default.
• W2530542011 hasConcept C2781107101 @default.
• W2530542011 hasConcept C2909962599 @default.
• W2530542011 hasConcept C71924100 @default.
• W2530542011 hasConceptScore W2530542011C126322002 @default.
• W2530542011 hasConceptScore W2530542011C187212893 @default.
• W2530542011 hasConceptScore W2530542011C205545832 @default.
• W2530542011 hasConceptScore W2530542011C2778461978 @default.
• W2530542011 hasConceptScore W2530542011C2778904437 @default.
• W2530542011 hasConceptScore W2530542011C2781107101 @default.
• W2530542011 hasConceptScore W2530542011C2909962599 @default.
• W2530542011 hasConceptScore W2530542011C71924100 @default.
• W2530542011 hasLocation W25305420111 @default.
• W2530542011 hasOpenAccess W2530542011 @default.
• W2530542011 hasPrimaryLocation W25305420111 @default.
• W2530542011 hasRelatedWork W1848817487 @default.
• W2530542011 hasRelatedWork W2060876075 @default.
• W2530542011 hasRelatedWork W2079183235 @default.
• W2530542011 hasRelatedWork W2146549434 @default.
• W2530542011 hasRelatedWork W2174266395 @default.
• W2530542011 hasRelatedWork W2192942249 @default.
• W2530542011 hasRelatedWork W2313381250 @default.
• W2530542011 hasRelatedWork W2439582734 @default.
• W2530542011 hasRelatedWork W2525152164 @default.
• W2530542011 hasRelatedWork W2530737867 @default.
• W2530542011 hasRelatedWork W2587999723 @default.
• W2530542011 hasRelatedWork W2595655574 @default.
• W2530542011 hasRelatedWork W2687423206 @default.
• W2530542011 hasRelatedWork W2788285407 @default.
• W2530542011 hasRelatedWork W2945001473 @default.
• W2530542011 hasRelatedWork W2972915484 @default.
• W2530542011 hasRelatedWork W2979441907 @default.
• W2530542011 hasRelatedWork W2984983099 @default.
• W2530542011 hasRelatedWork W3097918044 @default.
• W2530542011 hasRelatedWork W3126887153 @default.
• W2530542011 isParatext "false" @default.
• W2530542011 isRetracted "false" @default.
• W2530542011 magId "2530542011" @default.
• W2530542011 workType "article" @default.