Matches in SemOpenAlex for { <https://semopenalex.org/work/W2530564279> ?p ?o ?g. }
- W2530564279 endingPage "E740" @default.
- W2530564279 startingPage "E730" @default.
- W2530564279 abstract "Nonalcoholic fatty liver disease (NAFLD) is a growing worldwide epidemic and an important risk factor for the development of insulin resistance, type 2 diabetes, nonalcoholic steatohepatitis (NASH), and hepatic cellular carcinoma (HCC). Despite the prevalence of NAFLD, lifestyle interventions involving exercise and weight loss are the only accepted treatments for this disease. Over the last decade, numerous experimental compounds have been shown to improve NAFLD in preclinical animal models, and many of these therapeutics have been shown to increase the activity of the cellular energy sensor AMP-activated protein kinase (AMPK). Because AMPK activity is reduced by inflammation, obesity, and diabetes, increasing AMPK activity has been viewed as a viable therapeutic strategy to improve NAFLD. In this review, we propose three primary mechanisms by which AMPK activation may improve NAFLD. In addition, we examine the mechanisms by which AMPK is activated. Finally, we identify 27 studies that have used AMPK activators to reduce NAFLD. Future considerations for studies examining the relationship between AMPK and NAFLD are highlighted." @default.
- W2530564279 created "2016-10-21" @default.
- W2530564279 creator A5008099970 @default.
- W2530564279 creator A5024136956 @default.
- W2530564279 creator A5035427402 @default.
- W2530564279 creator A5064597054 @default.
- W2530564279 creator A5067222106 @default.
- W2530564279 creator A5067507899 @default.
- W2530564279 date "2016-10-01" @default.
- W2530564279 modified "2023-10-14" @default.
- W2530564279 title "Treatment of nonalcoholic fatty liver disease: role of AMPK" @default.
- W2530564279 cites W1196553794 @default.
- W2530564279 cites W1530129189 @default.
- W2530564279 cites W1555224456 @default.
- W2530564279 cites W1562737011 @default.
- W2530564279 cites W1597960787 @default.
- W2530564279 cites W1757356499 @default.
- W2530564279 cites W1761560590 @default.
- W2530564279 cites W1767926241 @default.
- W2530564279 cites W1799271499 @default.
- W2530564279 cites W1820085648 @default.
- W2530564279 cites W1845161096 @default.
- W2530564279 cites W1848278480 @default.
- W2530564279 cites W1856151485 @default.
- W2530564279 cites W1966706887 @default.
- W2530564279 cites W1967183094 @default.
- W2530564279 cites W1967410814 @default.
- W2530564279 cites W1973609430 @default.
- W2530564279 cites W1974094677 @default.
- W2530564279 cites W1974677595 @default.
- W2530564279 cites W1978763812 @default.
- W2530564279 cites W1980898941 @default.
- W2530564279 cites W1982126966 @default.
- W2530564279 cites W1982610311 @default.
- W2530564279 cites W1983011772 @default.
- W2530564279 cites W1985241942 @default.
- W2530564279 cites W1985592156 @default.
- W2530564279 cites W1985819704 @default.
- W2530564279 cites W1986375719 @default.
- W2530564279 cites W1988003144 @default.
- W2530564279 cites W1990197093 @default.
- W2530564279 cites W1992304595 @default.
- W2530564279 cites W1993849158 @default.
- W2530564279 cites W1995069275 @default.
- W2530564279 cites W1996234987 @default.
- W2530564279 cites W1996641308 @default.
- W2530564279 cites W2007486805 @default.
- W2530564279 cites W2010220662 @default.
- W2530564279 cites W2010238890 @default.
- W2530564279 cites W2010895111 @default.
- W2530564279 cites W2011001343 @default.
- W2530564279 cites W2011574523 @default.
- W2530564279 cites W2012295774 @default.
- W2530564279 cites W2012898950 @default.
- W2530564279 cites W2014770821 @default.
- W2530564279 cites W2017004251 @default.
- W2530564279 cites W2018445097 @default.
- W2530564279 cites W2019020570 @default.
- W2530564279 cites W2019374190 @default.
- W2530564279 cites W2019677361 @default.
- W2530564279 cites W2019973807 @default.
- W2530564279 cites W2020255363 @default.
- W2530564279 cites W2020351518 @default.
- W2530564279 cites W2021657723 @default.
- W2530564279 cites W2026413615 @default.
- W2530564279 cites W2026617356 @default.
- W2530564279 cites W2027886100 @default.
- W2530564279 cites W2031533316 @default.
- W2530564279 cites W2031980199 @default.
- W2530564279 cites W2033497590 @default.
- W2530564279 cites W2037918682 @default.
- W2530564279 cites W2038976751 @default.
- W2530564279 cites W2039212784 @default.
- W2530564279 cites W2040605398 @default.
- W2530564279 cites W2042981158 @default.
- W2530564279 cites W2046805974 @default.
- W2530564279 cites W2046822015 @default.
- W2530564279 cites W2048954429 @default.
- W2530564279 cites W2059196301 @default.
- W2530564279 cites W2062336519 @default.
- W2530564279 cites W2068387290 @default.
- W2530564279 cites W2069695193 @default.
- W2530564279 cites W2069986569 @default.
- W2530564279 cites W2070910260 @default.
- W2530564279 cites W2071975518 @default.
- W2530564279 cites W2072187728 @default.
- W2530564279 cites W2073563008 @default.
- W2530564279 cites W2075033432 @default.
- W2530564279 cites W2076581768 @default.
- W2530564279 cites W2080481362 @default.
- W2530564279 cites W2084461928 @default.
- W2530564279 cites W2085558309 @default.
- W2530564279 cites W2085567056 @default.
- W2530564279 cites W2086204033 @default.
- W2530564279 cites W2088769174 @default.
- W2530564279 cites W2090036126 @default.
- W2530564279 cites W2091450162 @default.
- W2530564279 cites W2091469763 @default.