FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2530758423> ?p ?o ?g. }

• W2530758423 endingPage "1212" @default.
• W2530758423 startingPage "1208" @default.
• W2530758423 abstract "High throughput screening of insulin secretion is intractable with current methods. We developed a secreted insulin-luciferase system (Ins-GLuc) in β cells that is rapid, inexpensive, and amenable to 96- and 384-well formats. We treated stable Ins-GLuc-expressing MIN6 cells overnight with 6298 marine natural product fractions. The cells were then washed to remove media and chemicals, followed by stimulation with glucose in the diazoxide paradigm. These conditions allowed the discovery of many insulin secretion suppressors and potentiators. The mechanisms of action of these natural products must be long-lasting given the continuance of secretory phenotypes in the absence of chemical treatment. We anticipate that these natural products and their target pathways will lead to a greater understanding of glucose-stimulated insulin secretion." @default.
• W2530758423 created "2016-10-21" @default.
• W2530758423 creator A5004184923 @default.
• W2530758423 creator A5022268890 @default.
• W2530758423 creator A5048922146 @default.
• W2530758423 creator A5056347853 @default.
• W2530758423 creator A5058755648 @default.
• W2530758423 creator A5062738955 @default.
• W2530758423 creator A5073990084 @default.
• W2530758423 creator A5074517766 @default.
• W2530758423 creator A5075386439 @default.
• W2530758423 date "2016-10-14" @default.
• W2530758423 modified "2023-10-09" @default.
• W2530758423 title "Insulin Promoter-Driven <i>Gaussia</i> Luciferase-Based Insulin Secretion Biosensor Assay for Discovery of β-Cell Glucose-Sensing Pathways" @default.
• W2530758423 cites W1591311438 @default.
• W2530758423 cites W1954684818 @default.
• W2530758423 cites W1965300532 @default.
• W2530758423 cites W1970473761 @default.
• W2530758423 cites W1981137172 @default.
• W2530758423 cites W1981248694 @default.
• W2530758423 cites W1994924615 @default.
• W2530758423 cites W1999937387 @default.
• W2530758423 cites W2020221058 @default.
• W2530758423 cites W2048065530 @default.
• W2530758423 cites W2065673503 @default.
• W2530758423 cites W2081595122 @default.
• W2530758423 cites W2088160164 @default.
• W2530758423 cites W2090433349 @default.
• W2530758423 cites W2112728838 @default.
• W2530758423 cites W2114329214 @default.
• W2530758423 cites W2128167237 @default.
• W2530758423 cites W2129393307 @default.
• W2530758423 cites W2141363931 @default.
• W2530758423 cites W2156818498 @default.
• W2530758423 cites W2346179007 @default.
• W2530758423 doi "https://doi.org/10.1021/acssensors.6b00433" @default.
• W2530758423 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5089812" @default.
• W2530758423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28723136" @default.
• W2530758423 hasPublicationYear "2016" @default.
• W2530758423 type Work @default.
• W2530758423 sameAs 2530758423 @default.
• W2530758423 citedByCount "34" @default.
• W2530758423 countsByYear W25307584232017 @default.
• W2530758423 countsByYear W25307584232018 @default.
• W2530758423 countsByYear W25307584232019 @default.
• W2530758423 countsByYear W25307584232020 @default.
• W2530758423 countsByYear W25307584232021 @default.
• W2530758423 countsByYear W25307584232022 @default.
• W2530758423 countsByYear W25307584232023 @default.
• W2530758423 crossrefType "journal-article" @default.
• W2530758423 hasAuthorship W2530758423A5004184923 @default.
• W2530758423 hasAuthorship W2530758423A5022268890 @default.
• W2530758423 hasAuthorship W2530758423A5048922146 @default.
• W2530758423 hasAuthorship W2530758423A5056347853 @default.
• W2530758423 hasAuthorship W2530758423A5058755648 @default.
• W2530758423 hasAuthorship W2530758423A5062738955 @default.
• W2530758423 hasAuthorship W2530758423A5073990084 @default.
• W2530758423 hasAuthorship W2530758423A5074517766 @default.
• W2530758423 hasAuthorship W2530758423A5075386439 @default.
• W2530758423 hasBestOaLocation W25307584232 @default.
• W2530758423 hasConcept C104317684 @default.
• W2530758423 hasConcept C111335760 @default.
• W2530758423 hasConcept C134018914 @default.
• W2530758423 hasConcept C185592680 @default.
• W2530758423 hasConcept C2779306644 @default.
• W2530758423 hasConcept C2779872217 @default.
• W2530758423 hasConcept C49039625 @default.
• W2530758423 hasConcept C54009773 @default.
• W2530758423 hasConcept C55493867 @default.
• W2530758423 hasConcept C86803240 @default.
• W2530758423 hasConceptScore W2530758423C104317684 @default.
• W2530758423 hasConceptScore W2530758423C111335760 @default.
• W2530758423 hasConceptScore W2530758423C134018914 @default.
• W2530758423 hasConceptScore W2530758423C185592680 @default.
• W2530758423 hasConceptScore W2530758423C2779306644 @default.
• W2530758423 hasConceptScore W2530758423C2779872217 @default.
• W2530758423 hasConceptScore W2530758423C49039625 @default.
• W2530758423 hasConceptScore W2530758423C54009773 @default.
• W2530758423 hasConceptScore W2530758423C55493867 @default.
• W2530758423 hasConceptScore W2530758423C86803240 @default.
• W2530758423 hasFunder F4320337351 @default.
• W2530758423 hasFunder F4320337357 @default.
• W2530758423 hasFunder F4320337593 @default.
• W2530758423 hasIssue "10" @default.
• W2530758423 hasLocation W25307584231 @default.
• W2530758423 hasLocation W25307584232 @default.
• W2530758423 hasLocation W25307584233 @default.
• W2530758423 hasLocation W25307584234 @default.
• W2530758423 hasOpenAccess W2530758423 @default.
• W2530758423 hasPrimaryLocation W25307584231 @default.
• W2530758423 hasRelatedWork W1849890897 @default.
• W2530758423 hasRelatedWork W1967289074 @default.
• W2530758423 hasRelatedWork W1992815116 @default.
• W2530758423 hasRelatedWork W1998988989 @default.
• W2530758423 hasRelatedWork W2003835703 @default.
• W2530758423 hasRelatedWork W2017432215 @default.
• W2530758423 hasRelatedWork W2053254447 @default.
• W2530758423 hasRelatedWork W2112420857 @default.

• next