FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2530759241> ?p ?o ?g. }

• W2530759241 endingPage "81" @default.
• W2530759241 startingPage "75" @default.
• W2530759241 abstract "Male infertility is a major health problem worldwide. Oligospermia and azoospermia are the most common symptoms of this disorder. Despite recent advances, the aetiopathogenesis of defective spermatogenesis remains largely uncertain. The aim of this study is to discover unknown or novel chromosome aberrations associated with male reproductive failure. We developed a high-resolution custom array comparative genomic hybridization for initial screening of copy number variations in 10 patients with idiopathic oligozoospermia and azoospermia and eight normal fertile men. We found that deletions were mainly located in the deleted-in-azoospermia subregion and were confined to patients. More importantly, an interesting microdeletion of the Y chromosome designated as D01 was detected in four out of 10 patients with oligozoospermia and azoospermia. We validated this recurrent deletion in nine out of 100 additional infertile men using polymerase chain reaction assays, whereas, it was not present in 100 proven fertile controls(P = 0.002). Furthermore, a bioinformatics analysis demonstrated that the 5' terminal of D01 is situated proximal to several conserved transcription factor binding sites within the Y chromosome. Our study indicated that this newly identified Y chromosome deletion might be potentially associated with impaired spermatogenesis and it is worthy of further investigations in larger cohorts." @default.
• W2530759241 created "2016-10-21" @default.
• W2530759241 creator A5007658688 @default.
• W2530759241 creator A5022320639 @default.
• W2530759241 creator A5033299593 @default.
• W2530759241 creator A5035426620 @default.
• W2530759241 creator A5066599847 @default.
• W2530759241 creator A5067614932 @default.
• W2530759241 creator A5073156180 @default.
• W2530759241 creator A5076453302 @default.
• W2530759241 creator A5078936866 @default.
• W2530759241 creator A5090289341 @default.
• W2530759241 creator A5091197146 @default.
• W2530759241 date "2017-01-01" @default.
• W2530759241 modified "2023-10-18" @default.
• W2530759241 title "A novel Y chromosome microdeletion potentially associated with defective spermatogenesis identified by custom array comparative genome hybridization" @default.
• W2530759241 cites W1536502843 @default.
• W2530759241 cites W1967368474 @default.
• W2530759241 cites W1972986614 @default.
• W2530759241 cites W1989153414 @default.
• W2530759241 cites W2001959835 @default.
• W2530759241 cites W2002314897 @default.
• W2530759241 cites W2002582503 @default.
• W2530759241 cites W2013660548 @default.
• W2530759241 cites W2021087963 @default.
• W2530759241 cites W2035213969 @default.
• W2530759241 cites W2042478514 @default.
• W2530759241 cites W2045040686 @default.
• W2530759241 cites W2050200195 @default.
• W2530759241 cites W2069277865 @default.
• W2530759241 cites W2078075583 @default.
• W2530759241 cites W2091655549 @default.
• W2530759241 cites W2097140644 @default.
• W2530759241 cites W2098213887 @default.
• W2530759241 cites W2102619694 @default.
• W2530759241 cites W2108967510 @default.
• W2530759241 cites W2112482499 @default.
• W2530759241 cites W2116753165 @default.
• W2530759241 cites W2121778192 @default.
• W2530759241 cites W2128376740 @default.
• W2530759241 cites W2129624444 @default.
• W2530759241 cites W2133174470 @default.
• W2530759241 cites W2140810913 @default.
• W2530759241 cites W2142974235 @default.
• W2530759241 cites W2145944312 @default.
• W2530759241 cites W2161414825 @default.
• W2530759241 cites W2165962943 @default.
• W2530759241 cites W2168267304 @default.
• W2530759241 cites W2170814454 @default.
• W2530759241 cites W2320043328 @default.
• W2530759241 cites W4233905353 @default.
• W2530759241 doi "https://doi.org/10.1016/j.rbmo.2016.09.010" @default.
• W2530759241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28341418" @default.
• W2530759241 hasPublicationYear "2017" @default.
• W2530759241 type Work @default.
• W2530759241 sameAs 2530759241 @default.
• W2530759241 citedByCount "4" @default.
• W2530759241 countsByYear W25307592412017 @default.
• W2530759241 countsByYear W25307592412019 @default.
• W2530759241 countsByYear W25307592412023 @default.
• W2530759241 crossrefType "journal-article" @default.
• W2530759241 hasAuthorship W2530759241A5007658688 @default.
• W2530759241 hasAuthorship W2530759241A5022320639 @default.
• W2530759241 hasAuthorship W2530759241A5033299593 @default.
• W2530759241 hasAuthorship W2530759241A5035426620 @default.
• W2530759241 hasAuthorship W2530759241A5066599847 @default.
• W2530759241 hasAuthorship W2530759241A5067614932 @default.
• W2530759241 hasAuthorship W2530759241A5073156180 @default.
• W2530759241 hasAuthorship W2530759241A5076453302 @default.
• W2530759241 hasAuthorship W2530759241A5078936866 @default.
• W2530759241 hasAuthorship W2530759241A5090289341 @default.
• W2530759241 hasAuthorship W2530759241A5091197146 @default.
• W2530759241 hasBestOaLocation W25307592411 @default.
• W2530759241 hasConcept C104317684 @default.
• W2530759241 hasConcept C122735190 @default.
• W2530759241 hasConcept C123765429 @default.
• W2530759241 hasConcept C124942203 @default.
• W2530759241 hasConcept C134018914 @default.
• W2530759241 hasConcept C206625514 @default.
• W2530759241 hasConcept C2776029846 @default.
• W2530759241 hasConcept C2777338322 @default.
• W2530759241 hasConcept C2777358149 @default.
• W2530759241 hasConcept C2777420699 @default.
• W2530759241 hasConcept C2777688143 @default.
• W2530759241 hasConcept C2779234561 @default.
• W2530759241 hasConcept C2780246931 @default.
• W2530759241 hasConcept C2780424099 @default.
• W2530759241 hasConcept C30481170 @default.
• W2530759241 hasConcept C54355233 @default.
• W2530759241 hasConcept C86803240 @default.
• W2530759241 hasConceptScore W2530759241C104317684 @default.
• W2530759241 hasConceptScore W2530759241C122735190 @default.
• W2530759241 hasConceptScore W2530759241C123765429 @default.
• W2530759241 hasConceptScore W2530759241C124942203 @default.
• W2530759241 hasConceptScore W2530759241C134018914 @default.
• W2530759241 hasConceptScore W2530759241C206625514 @default.
• W2530759241 hasConceptScore W2530759241C2776029846 @default.
• W2530759241 hasConceptScore W2530759241C2777338322 @default.

• next