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- W2530775469 abstract "We show that ionizing radiation modulates the dynamic association of the RNAbinding protein HuR with target mRNAs in an ATM-dependent manner, potentially coordinating the genotoxic response as an RNA operon. Pharmacologic ATM inhibition and use of ATM-null cells revealed a critical role for ATM in this process. Numerous mRNAs encoding cancer-related proteins were differentially associated with HuR depending on the functional state of ATM, in turn affecting expression of encoded proteins. The findings presented here reveal a previously unidentified role of ATM in controlling gene expression posttranscriptionally. Dysregulation of this DNA damage response RNA operon is probably relevant to lymphoma development in ataxiatelangiectasia persons. These novel RNA regulatory modules and genetic networks provide critical insight into the function of ATM in oncogenesis. (Blood. 2011; 117(8):2441-2450)" @default.
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- W2530775469 date "2016-01-01" @default.
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- W2530775469 title "ATM regulates a DNAdamage response posttranscriptional RNAoperon in lymphocytes" @default.
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