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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2530820912> ?p ?o ?g. }

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• W2530820912 abstract "Abstract A general method for transition metal‐free N ‐arylation of amines has been developed. Mechanistic studies have revealed that the ability of the base to facilitate the desired amination without promoting unwanted side reactions is the guiding factor. By employing lithium bis(trimethylsilyl)amide as a base the resultant deprotonated amines readily react with a range of unactivated fluorobenzene derivatives. This new arylation method is utilized for the simple two‐step synthesis of the antidepressant Vortioxetine." @default.
• W2530820912 created "2016-10-21" @default.
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• W2530820912 date "2016-12-13" @default.
• W2530820912 modified "2023-10-16" @default.
• W2530820912 title "Mechanism and Scope of Base-Controlled Catalyst-Free N-Arylation of Amines with Unactivated Fluorobenzenes" @default.
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• W2530820912 doi "https://doi.org/10.1002/chem.201604098" @default.
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