FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2530849596> ?p ?o ?g. }

• W2530849596 endingPage "144" @default.
• W2530849596 startingPage "134" @default.
• W2530849596 abstract "Behçet's disease (BD), an auto-inflammatory vasculitis with oro-genital ulcerations, skin lesions and uveitis, is regarded as T cell mediated. A successful trial with rituximab suggests an additive role for B cells in the pathogenesis. Therefore, we studied B cell abnormalities in BD patients and the effect of TNF-blocking therapy.B cells in blood (n = 36) and tissue (n = 6) of BD patients were analysed with flow cytometry and/or immunohistochemistry and compared with healthy controls (n = 22). BD current activity form (BDCAF) in relation to B cell somatic hypermutations (SHMs) and immunoglobulin class-switching were studied.Thirty-six patients (17 males) were included, mean age 44 years, average disease duration 10 years and mean BDCAF 2.7. Blood B cell numbers were significantly lower in patients than in controls (P = 0.0061), mostly due to decreased CD27+ memory B cells expressing IgM (P = 0.0001), IgG (P = 0.0002) and IgA (P = 0.0038) B cell subsets. CD27+ IgA+ B cells showed the highest magnitude of decrease in active disease, measured with BDCAF (P = 0.02). CD27+ IgM+ IgD+ B cells were impaired in replication history (P = 0.0133) and selection of SHM, whereas IgA+ B cells carried elevated SHM levels (P = 0.04) and lower IgA2 subclass usage (P = 0.0004) than controls. Immunohistochemistry revealed B cells in tissue of active mucosal ulcers. In adalimumab-treated patients, blood B cells were similar to controls.We show significant deviations in the memory B cell compartment, related to disease activity and therapeutic efficacy. Pronounced molecular impairments were seen in the fast-responding IgM+-memory and the mucosal IgA+-memory B cells. Because of the demonstrated abundance of B cells in affected tissue, we hypothesize relocation of memory B cells to the site of inflammation could account for the deviations found in blood of BD patients. These peripheral B cells are easily accessible as a marker to monitor therapeutic efficacy." @default.
• W2530849596 created "2016-10-21" @default.
• W2530849596 creator A5006831653 @default.
• W2530849596 creator A5010934588 @default.
• W2530849596 creator A5013309397 @default.
• W2530849596 creator A5015653388 @default.
• W2530849596 creator A5053851384 @default.
• W2530849596 creator A5062554397 @default.
• W2530849596 creator A5064083413 @default.
• W2530849596 creator A5073078630 @default.
• W2530849596 date "2016-10-15" @default.
• W2530849596 modified "2023-10-01" @default.
• W2530849596 title "Chronic signs of memory B cell activation in patients with Behçet’s disease are partially restored by anti-tumour necrosis factor treatment" @default.
• W2530849596 cites W1782798663 @default.
• W2530849596 cites W1925889097 @default.
• W2530849596 cites W1965272893 @default.
• W2530849596 cites W1966524332 @default.
• W2530849596 cites W2005988541 @default.
• W2530849596 cites W2007631332 @default.
• W2530849596 cites W2008838198 @default.
• W2530849596 cites W2011136801 @default.
• W2530849596 cites W2020905367 @default.
• W2530849596 cites W2022391508 @default.
• W2530849596 cites W2028078512 @default.
• W2530849596 cites W2038598165 @default.
• W2530849596 cites W2053358568 @default.
• W2530849596 cites W2058796168 @default.
• W2530849596 cites W2089392021 @default.
• W2530849596 cites W2098330802 @default.
• W2530849596 cites W2102771576 @default.
• W2530849596 cites W2105273832 @default.
• W2530849596 cites W2114162691 @default.
• W2530849596 cites W2129840266 @default.
• W2530849596 cites W2134293291 @default.
• W2530849596 cites W2141315578 @default.
• W2530849596 cites W2142473469 @default.
• W2530849596 cites W2147507344 @default.
• W2530849596 cites W2150247134 @default.
• W2530849596 cites W2153710191 @default.
• W2530849596 cites W2160536241 @default.
• W2530849596 cites W2167108967 @default.
• W2530849596 cites W2168379509 @default.
• W2530849596 cites W2171744407 @default.
• W2530849596 cites W2172998032 @default.
• W2530849596 cites W2322373306 @default.
• W2530849596 doi "https://doi.org/10.1093/rheumatology/kew366" @default.
• W2530849596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27744360" @default.
• W2530849596 hasPublicationYear "2016" @default.
• W2530849596 type Work @default.
• W2530849596 sameAs 2530849596 @default.
• W2530849596 citedByCount "12" @default.
• W2530849596 countsByYear W25308495962017 @default.
• W2530849596 countsByYear W25308495962018 @default.
• W2530849596 countsByYear W25308495962019 @default.
• W2530849596 countsByYear W25308495962020 @default.
• W2530849596 countsByYear W25308495962021 @default.
• W2530849596 countsByYear W25308495962022 @default.
• W2530849596 countsByYear W25308495962023 @default.
• W2530849596 crossrefType "journal-article" @default.
• W2530849596 hasAuthorship W2530849596A5006831653 @default.
• W2530849596 hasAuthorship W2530849596A5010934588 @default.
• W2530849596 hasAuthorship W2530849596A5013309397 @default.
• W2530849596 hasAuthorship W2530849596A5015653388 @default.
• W2530849596 hasAuthorship W2530849596A5053851384 @default.
• W2530849596 hasAuthorship W2530849596A5062554397 @default.
• W2530849596 hasAuthorship W2530849596A5064083413 @default.
• W2530849596 hasAuthorship W2530849596A5073078630 @default.
• W2530849596 hasBestOaLocation W25308495961 @default.
• W2530849596 hasConcept C126322002 @default.
• W2530849596 hasConcept C159654299 @default.
• W2530849596 hasConcept C203014093 @default.
• W2530849596 hasConcept C2776015282 @default.
• W2530849596 hasConcept C2778453870 @default.
• W2530849596 hasConcept C2779134260 @default.
• W2530849596 hasConcept C2779359726 @default.
• W2530849596 hasConcept C2780942790 @default.
• W2530849596 hasConcept C2781428731 @default.
• W2530849596 hasConcept C48010095 @default.
• W2530849596 hasConcept C71924100 @default.
• W2530849596 hasConceptScore W2530849596C126322002 @default.
• W2530849596 hasConceptScore W2530849596C159654299 @default.
• W2530849596 hasConceptScore W2530849596C203014093 @default.
• W2530849596 hasConceptScore W2530849596C2776015282 @default.
• W2530849596 hasConceptScore W2530849596C2778453870 @default.
• W2530849596 hasConceptScore W2530849596C2779134260 @default.
• W2530849596 hasConceptScore W2530849596C2779359726 @default.
• W2530849596 hasConceptScore W2530849596C2780942790 @default.
• W2530849596 hasConceptScore W2530849596C2781428731 @default.
• W2530849596 hasConceptScore W2530849596C48010095 @default.
• W2530849596 hasConceptScore W2530849596C71924100 @default.
• W2530849596 hasIssue "1" @default.
• W2530849596 hasLocation W25308495961 @default.
• W2530849596 hasLocation W25308495962 @default.
• W2530849596 hasOpenAccess W2530849596 @default.
• W2530849596 hasPrimaryLocation W25308495961 @default.
• W2530849596 hasRelatedWork W1872184414 @default.
• W2530849596 hasRelatedWork W2003525728 @default.
• W2530849596 hasRelatedWork W2008212248 @default.

• next