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- W2530885229 abstract "Neurosteroids are key endogenous molecules in the brain that affect many neural functions. We describe here recent advances in US National Institutes of Health (NIH)-sponsored and other clinical studies of neurosteroids for CNS disorders. The neuronal GABA-A receptor chloride channel is one of the prime molecular targets of neurosteroids. Allopregnanolone-like neurosteroids are potent allosteric agonists as well as direct activators of both synaptic and extrasynaptic GABA-A receptors. Hence, neurosteroids can maximally enhance synaptic phasic and extrasynaptic tonic inhibition. The resulting chloride current conductance generates a form of shunting inhibition that controls network excitability, seizures, and behavior. Such mechanisms of neurosteroids are providing innovative therapies for epilepsy, status epilepticus (SE), traumatic brain injury (TBI), fragile X syndrome (FXS), and chemical neurotoxicity. The neurosteroid field has entered a new era, and many compounds have reached advanced clinical trials. Synthetic analogs have several advantages over natural neurosteroids for clinical use because of their superior bioavailability and safety trends." @default.
- W2530885229 created "2016-10-21" @default.
- W2530885229 creator A5043518975 @default.
- W2530885229 creator A5078257145 @default.
- W2530885229 date "2016-01-01" @default.
- W2530885229 modified "2023-09-24" @default.
- W2530885229 title "Clinical Potential of Neurosteroids for CNS" @default.
- W2530885229 cites W1504424992 @default.
- W2530885229 cites W15119525 @default.
- W2530885229 cites W1552482204 @default.
- W2530885229 cites W1561083615 @default.
- W2530885229 cites W1589666289 @default.
- W2530885229 cites W1607421315 @default.
- W2530885229 cites W1898065702 @default.
- W2530885229 cites W1904830797 @default.
- W2530885229 cites W1922154348 @default.
- W2530885229 cites W1939084108 @default.
- W2530885229 cites W1965738886 @default.
- W2530885229 cites W1966695200 @default.
- W2530885229 cites W1968672320 @default.
- W2530885229 cites W1976278777 @default.
- W2530885229 cites W1980923887 @default.
- W2530885229 cites W1983034344 @default.
- W2530885229 cites W1984548667 @default.
- W2530885229 cites W1984582983 @default.
- W2530885229 cites W1986124039 @default.
- W2530885229 cites W1992160317 @default.
- W2530885229 cites W1995800128 @default.
- W2530885229 cites W1997491810 @default.
- W2530885229 cites W1998236920 @default.
- W2530885229 cites W1999602956 @default.
- W2530885229 cites W2002358253 @default.
- W2530885229 cites W2002604524 @default.
- W2530885229 cites W2005996041 @default.
- W2530885229 cites W2007736756 @default.
- W2530885229 cites W2010743538 @default.
- W2530885229 cites W2014271878 @default.
- W2530885229 cites W2014370769 @default.
- W2530885229 cites W2014945515 @default.
- W2530885229 cites W2017227716 @default.
- W2530885229 cites W2018366528 @default.
- W2530885229 cites W2019879401 @default.
- W2530885229 cites W2020420256 @default.
- W2530885229 cites W2020886601 @default.
- W2530885229 cites W2025899299 @default.
- W2530885229 cites W2028058817 @default.
- W2530885229 cites W2030295462 @default.
- W2530885229 cites W2031193882 @default.
- W2530885229 cites W2031849673 @default.
- W2530885229 cites W2032508898 @default.
- W2530885229 cites W2033837647 @default.
- W2530885229 cites W2034095388 @default.
- W2530885229 cites W2039611421 @default.
- W2530885229 cites W2039701902 @default.
- W2530885229 cites W2040498823 @default.
- W2530885229 cites W2041337341 @default.
- W2530885229 cites W2042563099 @default.
- W2530885229 cites W2045673384 @default.
- W2530885229 cites W2046566032 @default.
- W2530885229 cites W2047157308 @default.
- W2530885229 cites W2050343921 @default.
- W2530885229 cites W2051056852 @default.
- W2530885229 cites W2055973066 @default.
- W2530885229 cites W2060647422 @default.
- W2530885229 cites W2060806258 @default.
- W2530885229 cites W2061012355 @default.
- W2530885229 cites W2061052720 @default.
- W2530885229 cites W2061947653 @default.
- W2530885229 cites W2064785985 @default.
- W2530885229 cites W2065598137 @default.
- W2530885229 cites W2071339887 @default.
- W2530885229 cites W2071797393 @default.
- W2530885229 cites W2072316582 @default.
- W2530885229 cites W2073971076 @default.
- W2530885229 cites W2074761408 @default.
- W2530885229 cites W2076224060 @default.
- W2530885229 cites W2076519993 @default.
- W2530885229 cites W2077182987 @default.
- W2530885229 cites W2077468380 @default.
- W2530885229 cites W2081631574 @default.
- W2530885229 cites W2083418663 @default.
- W2530885229 cites W2083447043 @default.
- W2530885229 cites W2087616446 @default.
- W2530885229 cites W2088143216 @default.
- W2530885229 cites W2088232735 @default.
- W2530885229 cites W2089265290 @default.
- W2530885229 cites W2095492353 @default.
- W2530885229 cites W2098185331 @default.
- W2530885229 cites W2101301851 @default.
- W2530885229 cites W2105580021 @default.
- W2530885229 cites W2109271430 @default.
- W2530885229 cites W2112264559 @default.
- W2530885229 cites W2118773914 @default.
- W2530885229 cites W2118826874 @default.
- W2530885229 cites W2121587872 @default.
- W2530885229 cites W2122861238 @default.
- W2530885229 cites W2125277337 @default.
- W2530885229 cites W2127146014 @default.
- W2530885229 cites W2131665713 @default.
- W2530885229 cites W2140155039 @default.