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- W2530905165 abstract "Rationale: Asthma is a chronic inflammatory disorder of the airways in which many cells and cellular elements playa role. Assessment of airway remodelling by analysis of blood and sputum markers has been developed as non-invasiveprocedures to bypass tissue biopsy.Aim of the work: evaluate the usefulness of estimation of serum TGF-β1, as non- invasive markers of airwayremodelling in patients with bronchial asthma and correlation between its level and degree of asthma control, severityand duration.Patients and Methods: the study included 68 asthmatics and 20 controls. They were classified according to levelof control, severity and duration. Blood samples were taken to estimate the serum levels of TGF-β1.Results: the serum level of TGF-β1 was significantly higher in asthmatics than controls and in patients withuncontrolled asthma compared to controlled (P<0.001). It was significantly higher in severe and moderate asthma thanwith mild asthma (P 5 years compared to disease duration <5 years(PE0.001). Significant positive correlation between TGF-β1 and FEV1 (P<0.001) were recorded.Conclusion: Serum TGF-β1 could be considered as non-invasive markers of airway remodelling, severity of airflowlimitation and as predictor of degree of asthma control." @default.
- W2530905165 created "2016-10-21" @default.
- W2530905165 creator A5016244243 @default.
- W2530905165 date "2015-01-01" @default.
- W2530905165 modified "2023-09-29" @default.
- W2530905165 title "Serum Transforming Growth Factor âÂÂò1 (TGF-ò1) in Asthmatics: Association between Disease Control, Severity and Duration" @default.
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- W2530905165 doi "https://doi.org/10.4172/2161-1009.1000200" @default.
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