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- W2530916980 abstract "The modular construction of Layer-by-Layer biopolymer microcarriers facilitates a highly specific design of drug delivery systems. A supported lipid bilayer (SLB) contributes to biocompatibility and protection of sensitive active agents. The addition of a lipid anchor equipped with PEG (shielding from opsonins) and biotin (attachment of exchangeable outer functional molecules) enhances the microcarrier functionality even more. However, a homogeneously assembled supported lipid bilayer is a prerequisite for a specific binding of functional components. Our investigations show that a tightly packed SLB improves the efficiency of functional components attached to the microcarrier’s surface, as illustrated with specific antibodies in cellular application. Only a low quantity of antibodies is needed to obtain improved cellular uptake rates independent from cell type as compared to an antibody-functionalized loosely packed lipid bilayer or directly assembled antibody onto the multilayer. A fast disassembly of the lipid bilayer within endolysosomes exposing the underlying drug delivering multilayer structure demonstrates the suitability of LbL-microcarriers as a multifunctional drug delivery system." @default.
- W2530916980 created "2016-10-21" @default.
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- W2530916980 creator A5012902674 @default.
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- W2530916980 date "2016-10-25" @default.
- W2530916980 modified "2023-09-26" @default.
- W2530916980 title "Specific Uptake of Lipid-Antibody-Functionalized LbL Microcarriers by Cells" @default.
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- W2530916980 doi "https://doi.org/10.1021/acs.biomac.6b01159" @default.
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