FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2530929651> ?p ?o ?g. }

• W2530929651 endingPage "150" @default.
• W2530929651 startingPage "140" @default.
• W2530929651 abstract "A common property of Cu/Zn superoxide dismutase 1 (SOD1), harboring mutations associated with amyotrophic lateral sclerosis, is a high propensity to misfold and form abnormal aggregates. The aggregation of mutant SOD1 has been demonstrated in vitro, with purified proteins, in mouse models, in human tissues, and in cultured cell models. In vitro translation studies have determined that SOD1 with amyotrophic lateral sclerosis mutations is slower to mature, and thus perhaps vulnerable to off-pathway folding that could generate aggregates. The aggregation of mutant SOD1 in living cells can be monitored by tagging the protein with fluorescent fluorophores. In this study, we have taken advantage of the Dendra2 fluorophore technology in which excitation can be used to switch the output color from green to red, thereby clearly creating a time stamp that distinguishes pre-existing and newly made proteins. In cells that transiently over-express the Ala 4 to Val variant of SOD1-Dendra2, we observed that newly made mutant SOD1 was rapidly captured by pathologic intracellular inclusions. In cell models of mutant SOD1 aggregation over-expressing untagged A4V-SOD1, we observed that immature forms of the protein, lacking a Cu co-factor and a normal intramolecular disulfide, persist for extended periods. Our findings fit with a model in which immature forms of mutant A4V-SOD1, including newly made protein, are prone to misfolding and aggregation." @default.
• W2530929651 created "2016-10-21" @default.
• W2530929651 creator A5001791933 @default.
• W2530929651 creator A5002907814 @default.
• W2530929651 creator A5021832997 @default.
• W2530929651 creator A5034424187 @default.
• W2530929651 creator A5038629622 @default.
• W2530929651 creator A5043721847 @default.
• W2530929651 creator A5047461991 @default.
• W2530929651 creator A5073896166 @default.
• W2530929651 creator A5088733841 @default.
• W2530929651 date "2016-11-25" @default.
• W2530929651 modified "2023-10-02" @default.
• W2530929651 title "Relationship between mutant Cu/Zn superoxide dismutase 1 maturation and inclusion formation in cell models" @default.
• W2530929651 cites W1964377967 @default.
• W2530929651 cites W1968735793 @default.
• W2530929651 cites W1974809155 @default.
• W2530929651 cites W1975473360 @default.
• W2530929651 cites W1975906144 @default.
• W2530929651 cites W1979535442 @default.
• W2530929651 cites W1982442386 @default.
• W2530929651 cites W1984589592 @default.
• W2530929651 cites W2004192426 @default.
• W2530929651 cites W2008639647 @default.
• W2530929651 cites W2013135033 @default.
• W2530929651 cites W2017042451 @default.
• W2530929651 cites W2022721388 @default.
• W2530929651 cites W2022933182 @default.
• W2530929651 cites W2022985370 @default.
• W2530929651 cites W2023459278 @default.
• W2530929651 cites W2024059905 @default.
• W2530929651 cites W2027426714 @default.
• W2530929651 cites W2030793256 @default.
• W2530929651 cites W2032107666 @default.
• W2530929651 cites W2040621074 @default.
• W2530929651 cites W2052274307 @default.
• W2530929651 cites W2052630549 @default.
• W2530929651 cites W2056447311 @default.
• W2530929651 cites W2057984805 @default.
• W2530929651 cites W2062694025 @default.
• W2530929651 cites W2067288722 @default.
• W2530929651 cites W2092082741 @default.
• W2530929651 cites W2096335797 @default.
• W2530929651 cites W2097742940 @default.
• W2530929651 cites W2099393326 @default.
• W2530929651 cites W2106392233 @default.
• W2530929651 cites W2107672209 @default.
• W2530929651 cites W2115453265 @default.
• W2530929651 cites W2130435783 @default.
• W2530929651 cites W2133408527 @default.
• W2530929651 cites W2133714529 @default.
• W2530929651 cites W2140982317 @default.
• W2530929651 cites W2143366726 @default.
• W2530929651 cites W2153899328 @default.
• W2530929651 cites W2157557701 @default.
• W2530929651 cites W2162589295 @default.
• W2530929651 cites W2172292968 @default.
• W2530929651 cites W2193543187 @default.
• W2530929651 cites W2256271877 @default.
• W2530929651 cites W2282619066 @default.
• W2530929651 cites W2346854440 @default.
• W2530929651 cites W4376522596 @default.
• W2530929651 doi "https://doi.org/10.1111/jnc.13864" @default.
• W2530929651 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5283795" @default.
• W2530929651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27727458" @default.
• W2530929651 hasPublicationYear "2016" @default.
• W2530929651 type Work @default.
• W2530929651 sameAs 2530929651 @default.
• W2530929651 citedByCount "14" @default.
• W2530929651 countsByYear W25309296512017 @default.
• W2530929651 countsByYear W25309296512018 @default.
• W2530929651 countsByYear W25309296512019 @default.
• W2530929651 countsByYear W25309296512020 @default.
• W2530929651 countsByYear W25309296512021 @default.
• W2530929651 countsByYear W25309296512022 @default.
• W2530929651 crossrefType "journal-article" @default.
• W2530929651 hasAuthorship W2530929651A5001791933 @default.
• W2530929651 hasAuthorship W2530929651A5002907814 @default.
• W2530929651 hasAuthorship W2530929651A5021832997 @default.
• W2530929651 hasAuthorship W2530929651A5034424187 @default.
• W2530929651 hasAuthorship W2530929651A5038629622 @default.
• W2530929651 hasAuthorship W2530929651A5043721847 @default.
• W2530929651 hasAuthorship W2530929651A5047461991 @default.
• W2530929651 hasAuthorship W2530929651A5073896166 @default.
• W2530929651 hasAuthorship W2530929651A5088733841 @default.
• W2530929651 hasBestOaLocation W25309296511 @default.
• W2530929651 hasConcept C104317684 @default.
• W2530929651 hasConcept C12554922 @default.
• W2530929651 hasConcept C136238340 @default.
• W2530929651 hasConcept C142724271 @default.
• W2530929651 hasConcept C143065580 @default.
• W2530929651 hasConcept C185592680 @default.
• W2530929651 hasConcept C202751555 @default.
• W2530929651 hasConcept C204328495 @default.
• W2530929651 hasConcept C2775838275 @default.
• W2530929651 hasConcept C2777615887 @default.
• W2530929651 hasConcept C2778004101 @default.
• W2530929651 hasConcept C2779134260 @default.

• next