FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2530942458> ?p ?o ?g. }

• W2530942458 endingPage "152" @default.
• W2530942458 startingPage "143" @default.
• W2530942458 abstract "The aims of this study were to determine the role of lipolysis in hypoglycaemia and define the underlying intracellular mechanisms. Nine healthy volunteers were randomised to treatment order of three different treatments (crossover design). Treatments were: (1) saline control; (2) hyperinsulinaemic hypoglycaemia (HH; i.v. bolus of 0.1 U/kg insulin); and (3) hyperinsulinaemic euglycaemia (HE; i.v. bolus of 0.1 U/kg insulin and 20% glucose). Inclusion criteria were that volunteers were healthy, aged >18 years, had a BMI between 19 and 26 kg/m2, and provided both written and oral informed consent. Exclusion criteria were the presence of a known chronic disease (including diabetes mellitus, epilepsy, ischaemic heart disease and cardiac arrhythmias) and regular use of prescription medication. The data was collected at the medical research facilities at Aarhus University Hospital, Denmark. The primary outcome was palmitic acid flux. Participants were blinded to intervention order, but caregivers were not. Adrenaline (epinephrine) and glucagon concentrations were higher during HH than during both HE and control treatments. NEFA levels and lipid oxidation rates (determined by indirect calorimetry) returned to control levels after 105 min. Palmitate flux was increased to control levels during HH (p = NS) and was more than twofold higher than during HE (overall mean difference between HH vs HE, 114 [95% CI 64, 165 μmol/min]; p < 0.001). In subcutaneous adipose tissue biopsies, we found elevated levels of hormone-sensitive lipase (HSL) and perilipin-1 phosphorylation 30 min after insulin injection during HH compared with both control and HE. There were no changes in the levels of adipose triglyceride lipase (ATGL), comparative gene identification-58 (CGI-58) or G0/G1 switch gene 2 (G0S2) proteins. Insulin-stimulated phosphorylation of Akt and mTOR were unaffected by hypoglycaemia. Expression of the G0S2 gene increased during HE and HH compared with control, without changes in ATGL (also known as PNPLA2) or CGI-58 (also known as ABHD5) mRNA levels. These findings suggest that NEFAs become a major fuel source during insulin-induced hypoglycaemia and that lipolysis may be an important component of the counter-regulatory response. These effects appear to be mediated by rapid stimulation of protein kinase A (PKA) and HSL, compatible with activation of the β-adrenergic catecholamine signalling pathway. ClinicalTrials.gov NCT01919788 The study was funded by Aarhus University, the Novo Nordisk Foundation and the KETO Study Group/Danish Agency for Science Technology and Innovation (grant no. 0603–00479, to NM)." @default.
• W2530942458 created "2016-10-21" @default.
• W2530942458 creator A5001772428 @default.
• W2530942458 creator A5021672623 @default.
• W2530942458 creator A5026426127 @default.
• W2530942458 creator A5030803630 @default.
• W2530942458 creator A5051841150 @default.
• W2530942458 creator A5060945070 @default.
• W2530942458 creator A5064270055 @default.
• W2530942458 creator A5088598369 @default.
• W2530942458 creator A5089709729 @default.
• W2530942458 date "2016-10-12" @default.
• W2530942458 modified "2023-09-27" @default.
• W2530942458 title "Effects of insulin-induced hypoglycaemia on lipolysis rate, lipid oxidation and adipose tissue signalling in human volunteers: a randomised clinical study" @default.
• W2530942458 cites W1590785164 @default.
• W2530942458 cites W1606245564 @default.
• W2530942458 cites W1787494974 @default.
• W2530942458 cites W1952942405 @default.
• W2530942458 cites W1966491679 @default.
• W2530942458 cites W1969641363 @default.
• W2530942458 cites W1969914910 @default.
• W2530942458 cites W1987849310 @default.
• W2530942458 cites W2009711859 @default.
• W2530942458 cites W2024765752 @default.
• W2530942458 cites W2050094130 @default.
• W2530942458 cites W2081254560 @default.
• W2530942458 cites W2082503906 @default.
• W2530942458 cites W2107353084 @default.
• W2530942458 cites W2111528176 @default.
• W2530942458 cites W2112562030 @default.
• W2530942458 cites W2130869931 @default.
• W2530942458 cites W2133270566 @default.
• W2530942458 cites W2136336031 @default.
• W2530942458 cites W2138605610 @default.
• W2530942458 cites W2144173589 @default.
• W2530942458 cites W2144741116 @default.
• W2530942458 cites W2152826474 @default.
• W2530942458 cites W2155682477 @default.
• W2530942458 cites W2156469236 @default.
• W2530942458 cites W2158273437 @default.
• W2530942458 cites W2169792155 @default.
• W2530942458 cites W2200889199 @default.
• W2530942458 cites W2230115230 @default.
• W2530942458 cites W2474405972 @default.
• W2530942458 cites W3188628058 @default.
• W2530942458 cites W4254695749 @default.
• W2530942458 doi "https://doi.org/10.1007/s00125-016-4126-x" @default.
• W2530942458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27734104" @default.
• W2530942458 hasPublicationYear "2016" @default.
• W2530942458 type Work @default.
• W2530942458 sameAs 2530942458 @default.
• W2530942458 citedByCount "18" @default.
• W2530942458 countsByYear W25309424582017 @default.
• W2530942458 countsByYear W25309424582018 @default.
• W2530942458 countsByYear W25309424582019 @default.
• W2530942458 countsByYear W25309424582020 @default.
• W2530942458 countsByYear W25309424582021 @default.
• W2530942458 countsByYear W25309424582022 @default.
• W2530942458 countsByYear W25309424582023 @default.
• W2530942458 crossrefType "journal-article" @default.
• W2530942458 hasAuthorship W2530942458A5001772428 @default.
• W2530942458 hasAuthorship W2530942458A5021672623 @default.
• W2530942458 hasAuthorship W2530942458A5026426127 @default.
• W2530942458 hasAuthorship W2530942458A5030803630 @default.
• W2530942458 hasAuthorship W2530942458A5051841150 @default.
• W2530942458 hasAuthorship W2530942458A5060945070 @default.
• W2530942458 hasAuthorship W2530942458A5064270055 @default.
• W2530942458 hasAuthorship W2530942458A5088598369 @default.
• W2530942458 hasAuthorship W2530942458A5089709729 @default.
• W2530942458 hasBestOaLocation W25309424581 @default.
• W2530942458 hasConcept C126322002 @default.
• W2530942458 hasConcept C134018914 @default.
• W2530942458 hasConcept C140985366 @default.
• W2530942458 hasConcept C142462285 @default.
• W2530942458 hasConcept C142724271 @default.
• W2530942458 hasConcept C171089720 @default.
• W2530942458 hasConcept C204787440 @default.
• W2530942458 hasConcept C27081682 @default.
• W2530942458 hasConcept C2778270857 @default.
• W2530942458 hasConcept C2779306644 @default.
• W2530942458 hasConcept C2780941825 @default.
• W2530942458 hasConcept C2993143319 @default.
• W2530942458 hasConcept C3013748606 @default.
• W2530942458 hasConcept C43376680 @default.
• W2530942458 hasConcept C512399662 @default.
• W2530942458 hasConcept C555293320 @default.
• W2530942458 hasConcept C71924100 @default.
• W2530942458 hasConcept C87813604 @default.
• W2530942458 hasConceptScore W2530942458C126322002 @default.
• W2530942458 hasConceptScore W2530942458C134018914 @default.
• W2530942458 hasConceptScore W2530942458C140985366 @default.
• W2530942458 hasConceptScore W2530942458C142462285 @default.
• W2530942458 hasConceptScore W2530942458C142724271 @default.
• W2530942458 hasConceptScore W2530942458C171089720 @default.
• W2530942458 hasConceptScore W2530942458C204787440 @default.
• W2530942458 hasConceptScore W2530942458C27081682 @default.
• W2530942458 hasConceptScore W2530942458C2778270857 @default.
• W2530942458 hasConceptScore W2530942458C2779306644 @default.

• next