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• W2530969703 abstract "Significance The ability of pathogenic microorganisms to acquire iron from heme has been shown to be a valid antimicrobial target. However, all of the known mechanisms for heme catabolism that lead to iron release in bacteria and higher eukaryotes are dependent on molecular oxygen as a cosubstrate. The human gut is dominated by strictly anaerobic bacteria, and in this work, we provide evidence for anaerobic heme degradation in enteric pathogens. The anaerobic mechanism is significantly different from what has been observed in other bacteria and may provide a unique opportunity for a new class of antimicrobial compounds." @default.
• W2530969703 created "2016-10-21" @default.
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• W2530969703 date "2016-10-10" @default.
• W2530969703 modified "2023-10-15" @default.
• W2530969703 title "Radical new paradigm for heme degradation in <i>Escherichia coli</i> O157:H7" @default.
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• W2530969703 doi "https://doi.org/10.1073/pnas.1603209113" @default.
• W2530969703 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5087033" @default.
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