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• W2531054429 abstract "Antiretroviral drug therapy (ART) effectively suppresses replication of both the immunodeficiency viruses, human (HIV) and simian (SIV); however, virus rebounds soon after ART is withdrawn. SIV-infected monkeys were treated with a 90-day course of ART initiated at 5 weeks post infection followed at 9 weeks post infection by infusions of a primatized monoclonal antibody against the α4β7 integrin administered every 3 weeks until week 32. These animals subsequently maintained low to undetectable viral loads and normal CD4+ T cell counts in plasma and gastrointestinal tissues for more than 9 months, even after all treatment was withdrawn. This combination therapy allows macaques to effectively control viremia and reconstitute their immune systems without a need for further therapy." @default.
• W2531054429 created "2016-10-21" @default.
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• W2531054429 date "2016-10-14" @default.
• W2531054429 modified "2023-10-17" @default.
• W2531054429 title "Sustained virologic control in SIV ⁺ macaques after antiretroviral and α ₄ β ₇ antibody therapy" @default.
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• W2531054429 doi "https://doi.org/10.1126/science.aag1276" @default.
• W2531054429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5405455" @default.
• W2531054429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27738167" @default.
• W2531054429 hasPublicationYear "2016" @default.
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