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- W2531113595 abstract "Understanding T cell immunity to cancer has allowed the development of a new form of cancer therapy, which makes use of genetically engineered T cells that have chimeric antigen T cell receptors or CAR T cells. This type of cancer immunotherapy has led to an exploration of the T cell immune system for T cells that can be genetically engineered to be efficient anti-cancer immunotherapeutic effector T cells. CD8+ cytotoxic T cells were the first candidates. However, now other T cells or T cell phenotypes are sought after because of their advanced effector functions and their ability to survive during the immunotherapy process. Th17, which can be created from naive T cells and more importantly from Tregs are able to not only survive for extended period in the body, but are also efficient effector T cells. This review will examine the epigenetic changes in the T cell genome related to the creation and derivation of the Th17/Treg cell phenotypes. Manipulation of two signature genes (ROR-γτ and Fox-P3) could result in the creation of new type of immunotherapeutic effector T cell. The use of Th17 cells for the immunotherapeutic treatment of cancer will depend on the ability to alter their function, modify their T cell receptors, and arrest phenotypic differentiation." @default.
- W2531113595 created "2016-10-21" @default.
- W2531113595 creator A5045588233 @default.
- W2531113595 date "2016-10-14" @default.
- W2531113595 modified "2023-09-26" @default.
- W2531113595 title "Th17 Cells: Can Epigenetic Manipulation and Artificial T cell Receptors Make Th17 cells Efficient Immunotherapeutic Anti-Tumor Effector T Cells?" @default.
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- W2531113595 doi "https://doi.org/10.15406/moji.2016.04.00119" @default.
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