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• W2531147360 abstract "The advent of modern genome sequencing techniques allows for a more stringent test of the neutrality hypothesis of Darwinian evolution, where all individuals have the same fitness. Using the individual based model of Wright and Fisher, we compute the amplitude of neutral aggregation in the genome space, i.e., the probability of finding two individuals at genetic (hamming) distance k as a function of genome size L, population size N and mutation probability per base nu. In well mixed populations, we show that for Nnutextless{}1/L, neutral aggregation is the dominant force and most individuals are found at short genetic distances from each other. For Nnutextgreater{}1 on the contrary, individuals are randomly dispersed in genome space. The results are extended to geographically dispersed population, where the controlling parameter is shown to be a combination of mutation and migration probability. The theory we develop can be used to test the neutrality hypothesis in various ecological and evolutionary systems." @default.
• W2531147360 created "2016-10-21" @default.
• W2531147360 creator A5086700483 @default.
• W2531147360 date "2017-01-06" @default.
• W2531147360 modified "2023-09-25" @default.
• W2531147360 title "Neutral aggregation in finite-length genotype space" @default.
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• W2531147360 doi "https://doi.org/10.1103/physreve.95.012402" @default.
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