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- W2531168801 abstract "Abstract Octopamine, one of the main insect biogenic amines, plays an important role in the control of fitness in D rosophila melanogaster M eigen. The present study examines the effects of a null mutation of the gene of the insulin‐like receptor substrate ( chico ), in the heterozygous state, on octopamine metabolism, heat stress resistance and fecundity of D . melanogaster . A rise in the activity of one of the key enzymes of octopamine synthesis, tyrosine decarboxylase, as well as that of an enzyme of its degradation, octopamine‐dependent N ‐acetyl transferase, is observed in chico 1/+ females. It is also found that the resistance to heat stress is decreased and fecundity is reduced dramatically in chico 1/+ flies. Such changes in these parameters in D . melanogaster females result from a rise in octopamine titre, which suggests that chico affects the octopamine level by regulating the activity of tyrosine decarboxylase." @default.
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- W2531168801 date "2016-10-07" @default.
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- W2531168801 title "Insulin-like receptor substrate genechicoregulates octopamine metabolism inDrosophila melanogaster" @default.
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- W2531168801 doi "https://doi.org/10.1111/phen.12173" @default.
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