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- W2531242046 abstract "The development of more effective therapy for patients with advanced ovarian cancer (FIGO Stages III-IV) represents the major challenge in the management of this disease. In the last decade the use of cisplatin-based combination chemo therapy has led to an increase in complete remission rates, a prolongation of disease-free survival, and an increase in overall survival compared to treatment with single alkylating agents. However, the vast majority of patients with ad vanced disease die of recurrent ovarian cancer due to the fact that drug-sensitive tumors frequently develop primary resistance to the initial combination, which is accompanied by broad cross-resistance to virtually all classes of antineoplastic drugs. Consequently, only 20%-25% of all patients with advanced stage ovarian cancer are alive 5 years after initiation of chemotherapy. It has also been recently demonstrated that the dose of cisplatin is a critical factor in obtaining optimum results in the treatment of patients with advanced disease [1]. while cisplatin doses up to 200 mg/m2 can be administered without dose-limiting nephrotoxicity by using vigorous saline hydration, the develop ment of peripheral neuropathy has limited the number of cycles of high-dose cisplatin which can routinely be administered. The major areas of clinical and laboratory research in ovarian cancer are therefore focused upon the following issues: (a) identifying mechanisms responsible for the multidrug resistance phe notype and developing therapeutic strategies capable of overcoming this form of drug resistance, (b) developing more effective ways to deliver platinum-based chemotherapy, and (c) determining the role of biological response modifiers in the therapy of patients with advanced disease, since it is unlikely that the mechanisms responsible for drug resistance will influence the cytotoxicity of biologicals." @default.
- W2531242046 created "2016-10-21" @default.
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- W2531242046 date "1989-01-01" @default.
- W2531242046 modified "2023-09-26" @default.
- W2531242046 title "Current Results and Therapeutic Issues" @default.
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