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• W2531260053 abstract "// Zhenze Zhao 1 , Xiuye Ma 2 , Spencer D. Shelton 1 , Derek C. Sung 3 , Monica Li 4 , Daniel Hernandez 5 , Maggie Zhang 6 , Michael D. Losiewicz 7 , Yidong Chen 8 , Alexander Pertsemlidis 2, 9, 10 , Xiaojie Yu 11 , Yuanhang Liu 11 , Liqin Du 1 1 Department of Chemistry and Biochemistry at Texas State University, San Marcos, Texas, USA 2 Greehey Children’s Cancer Research Institute at UT Health Science Center at San Antonio, San Antonio, Texas, USA 3 Division of Nutritional Sciences at Cornell University, Ithaca, New York, USA 4 University of Texas at Austin, Austin, Texas, USA 5 Department of Biology at Texas State University, San Marcos, Texas, USA 6 Department of Biology, College of Sciences, University of Texas at San Antonio, San Antonio, Texas, USA 7 Department of Chemistry & Biochemistry at St. Mary’s University, San Antonio, Texas, USA 8 Department of Epidemiology and Biostatistics, at UT Health Science Center at San Antonio, San Antonio, Texas, USA 9 Department of Pediatrics, at UT Health Science Center at San Antonio, San Antonio, Texas, USA 10 Cellular and Structural Biology, at UT Health Science Center at San Antonio, San Antonio, Texas, USA 11 Graduate School of Biomedical Sciences at UT Health Science Center at San Antonio, San Antonio, Texas, USA Correspondence to: Liqin Du, email: liqindu6@txstate.edu Keywords: neuroblastoma, microRNA, differentiation, MYCN Received: March 22, 2016     Accepted: September 13, 2016     Published: October 15, 2016 ABSTRACT MYCN amplification is the most common genetic alteration in neuroblastoma and plays a critical role in neuroblastoma tumorigenesis. MYCN regulates neuroblastoma cell differentiation, which is one of the mechanisms underlying its oncogenic function. We recently identified a group of differentiation-inducing microRNAs. Given the demonstrated inter-regulation between MYCN and microRNAs, we speculated that MYCN and the differentiation-inducing microRNAs might form an interaction network to control the differentiation of neuroblastoma cells. In this study, we found that eight of the thirteen differentiation-inducing microRNAs, miR-506-3p, miR-124-3p, miR-449a, miR-34a-5p, miR-449b-5p, miR-103a-3p, miR-2110 and miR-34b-5p, inhibit N-Myc expression by either directly targeting the MYCN 3’UTR or through indirect regulations. Further investigation showed that both MYCN-dependent and MYCN-independent pathways play roles in mediating the differentiation-inducing function of miR-506-3p and miR-449a, two microRNAs that dramatically down-regulate MYCN expression. On the other hand, we found that N-Myc inhibits the expression of multiple differentiation-inducing microRNAs, suggesting that these miRNAs play a role in mediating the function of MYCN. In examining the published dataset collected from clinical neuroblastoma specimens, we found that expressions of two miRNAs, miR-137 and miR-2110, were significantly anti-correlated with MYCN mRNA levels, suggesting their interactions with MYCN play a clinically-relevant role in maintaining the MYCN and miRNA expression levels in neuroblastoma. Our findings altogether suggest that MYCN and differentiation-inducing miRNAs form an interaction network that play an important role in neuroblastoma tumorigenesis through regulating cell differentiation." @default.
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• W2531260053 date "2016-10-15" @default.
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• W2531260053 title "A combined gene expression and functional study reveals the crosstalk between N-Myc and differentiation-inducing microRNAs in neuroblastoma cells" @default.
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• W2531260053 doi "https://doi.org/10.18632/oncotarget.12676" @default.
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