Matches in SemOpenAlex for { <https://semopenalex.org/work/W2531318652> ?p ?o ?g. }
- W2531318652 endingPage "333" @default.
- W2531318652 startingPage "322" @default.
- W2531318652 abstract "Fine particulate matter (PM 2.5) is the principal instigators of adverse health events, yet gaps still remain in understanding the mechanism mediating its toxic response. Similar to nanoparticles, PM 2.5, with large surface area to volume ratio, can absorb multipollutants in air, displaying toxicity profiles that are very different from those of coarse particles of the same composition. One particularly relevant interaction is that of PM 2.5 and the anthropogenic metals. In this study, we used carbon black nanoparticle (CBs) and metal ions as model materials to investigate the synergistic pulmonary toxicity and its mechanism. We demonstrated that excessive metal contaminants adsorbed on CBs contributed to the observed toxic effects both in vitro and in C57BL6 mice intratracheal instillation model. Significantly, we found that autophagy and lysosomal dysfunction accounted for the synergistic pulmonary toxic effect of co-exposure to CBs and metals. Our findings provide a new insight into understanding the toxicological and healthy effects of fine particles, which have potential to aid in mitigating their adverse health effect." @default.
- W2531318652 created "2016-10-21" @default.
- W2531318652 creator A5003322678 @default.
- W2531318652 creator A5008020941 @default.
- W2531318652 creator A5011940376 @default.
- W2531318652 creator A5022365417 @default.
- W2531318652 creator A5023285963 @default.
- W2531318652 creator A5026635482 @default.
- W2531318652 creator A5029810260 @default.
- W2531318652 creator A5034588020 @default.
- W2531318652 creator A5038463211 @default.
- W2531318652 creator A5045742158 @default.
- W2531318652 creator A5062765143 @default.
- W2531318652 creator A5071773009 @default.
- W2531318652 creator A5075460158 @default.
- W2531318652 creator A5077423550 @default.
- W2531318652 date "2017-01-01" @default.
- W2531318652 modified "2023-10-13" @default.
- W2531318652 title "Autophagy and lysosomal dysfunction: A new insight into mechanism of synergistic pulmonary toxicity of carbon black-metal ions co-exposure" @default.
- W2531318652 cites W1973635422 @default.
- W2531318652 cites W1977767269 @default.
- W2531318652 cites W1989690889 @default.
- W2531318652 cites W1994901986 @default.
- W2531318652 cites W2002788183 @default.
- W2531318652 cites W2003468313 @default.
- W2531318652 cites W2004809872 @default.
- W2531318652 cites W2004907056 @default.
- W2531318652 cites W2012117396 @default.
- W2531318652 cites W2025665129 @default.
- W2531318652 cites W2027797630 @default.
- W2531318652 cites W2031038502 @default.
- W2531318652 cites W2035164566 @default.
- W2531318652 cites W2053849251 @default.
- W2531318652 cites W2056124067 @default.
- W2531318652 cites W2057705151 @default.
- W2531318652 cites W2060183047 @default.
- W2531318652 cites W2060941625 @default.
- W2531318652 cites W2074565738 @default.
- W2531318652 cites W2077288509 @default.
- W2531318652 cites W2079628884 @default.
- W2531318652 cites W2082476985 @default.
- W2531318652 cites W2083784656 @default.
- W2531318652 cites W2086998651 @default.
- W2531318652 cites W2089849935 @default.
- W2531318652 cites W2095187475 @default.
- W2531318652 cites W2112162648 @default.
- W2531318652 cites W2119380384 @default.
- W2531318652 cites W2120166044 @default.
- W2531318652 cites W2124725549 @default.
- W2531318652 cites W2128030447 @default.
- W2531318652 cites W2130042267 @default.
- W2531318652 cites W2133413068 @default.
- W2531318652 cites W2142493719 @default.
- W2531318652 cites W2146737827 @default.
- W2531318652 cites W2150615939 @default.
- W2531318652 cites W2153867951 @default.
- W2531318652 cites W2154704691 @default.
- W2531318652 cites W2154952911 @default.
- W2531318652 cites W2155687923 @default.
- W2531318652 cites W2156130847 @default.
- W2531318652 cites W2157489799 @default.
- W2531318652 cites W2159171427 @default.
- W2531318652 cites W2161050915 @default.
- W2531318652 cites W2172134348 @default.
- W2531318652 cites W2326941785 @default.
- W2531318652 doi "https://doi.org/10.1016/j.carbon.2016.10.015" @default.
- W2531318652 hasPublicationYear "2017" @default.
- W2531318652 type Work @default.
- W2531318652 sameAs 2531318652 @default.
- W2531318652 citedByCount "27" @default.
- W2531318652 countsByYear W25313186522017 @default.
- W2531318652 countsByYear W25313186522018 @default.
- W2531318652 countsByYear W25313186522019 @default.
- W2531318652 countsByYear W25313186522020 @default.
- W2531318652 countsByYear W25313186522021 @default.
- W2531318652 countsByYear W25313186522022 @default.
- W2531318652 countsByYear W25313186522023 @default.
- W2531318652 crossrefType "journal-article" @default.
- W2531318652 hasAuthorship W2531318652A5003322678 @default.
- W2531318652 hasAuthorship W2531318652A5008020941 @default.
- W2531318652 hasAuthorship W2531318652A5011940376 @default.
- W2531318652 hasAuthorship W2531318652A5022365417 @default.
- W2531318652 hasAuthorship W2531318652A5023285963 @default.
- W2531318652 hasAuthorship W2531318652A5026635482 @default.
- W2531318652 hasAuthorship W2531318652A5029810260 @default.
- W2531318652 hasAuthorship W2531318652A5034588020 @default.
- W2531318652 hasAuthorship W2531318652A5038463211 @default.
- W2531318652 hasAuthorship W2531318652A5045742158 @default.
- W2531318652 hasAuthorship W2531318652A5062765143 @default.
- W2531318652 hasAuthorship W2531318652A5071773009 @default.
- W2531318652 hasAuthorship W2531318652A5075460158 @default.
- W2531318652 hasAuthorship W2531318652A5077423550 @default.
- W2531318652 hasConcept C104779481 @default.
- W2531318652 hasConcept C107872376 @default.
- W2531318652 hasConcept C111472728 @default.
- W2531318652 hasConcept C116263406 @default.
- W2531318652 hasConcept C12554922 @default.
- W2531318652 hasConcept C138885662 @default.