FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2531319683> ?p ?o ?g. }

• W2531319683 endingPage "194" @default.
• W2531319683 startingPage "194" @default.
• W2531319683 abstract "<h3>Importance</h3> Metastatic colorectal cancer (mCRC) is heterogeneous, and primary tumors arising from different regions of the colon are clinically and molecularly distinct. <h3>Objective</h3> To examine the prognostic and predictive value of primary tumor location in patients with<i>RAS </i>wild-type (wt) mCRC treated with first-line fluorouracil, leucovorin, and irinotecan (FOLFIRI) plus cetuximab in the Cetuximab Combined With Irinotecan in First-line Therapy for Metastatic Colorectal Cancer (CRYSTAL) trial and FOLFIRI Plus Cetuximab Versus FOLFIRI Plus Bevacizumab as First-Line Treatment For Patients With Metastatic Colorectal Cancer (FIRE-3) trial. <h3>Design, Setting, and Participants</h3> In this retrospective analysis patients with<i>RAS</i>wt metastatic colorectal cancer from the CRYSTAL and FIRE-3 trials were classified as having left-sided or right-sided mCRC, defined, respectively, as patients whose tumors originated in the splenic flexure, descending colon, sigmoid colon, or rectum vs appendix, cecum, ascending colon, hepatic flexure, or transverse colon. <h3>Main Outcomes and Measures</h3> Progression-free survival (PFS), overall survival (OS), and objective response rate (ORR) were assessed according to tumor location and treatment arm. <h3>Results</h3> In the<i>RAS</i>wt populations of the CRYSTAL and FIRE-3 trials, patients with left-sided tumors (n = 142 and n = 157, respectively) had markedly superior PFS, OS, and ORR compared with patients with right-sided tumors (n = 33 and n = 38, respectively). Among CRYSTAL and FIRE-3 study patients with<i>RAS</i>wt left-sided tumors, FOLFIRI plus cetuximab significantly improved OS relative to the respective comparators (FOLFIRI and FOLFIRI plus bevacizumab); in contrast, in<i>RAS</i>wt patients with poor-prognosis right-sided tumors, limited efficacy benefits were observed upon the addition of cetuximab to FOLFIRI in CRYSTAL, and comparable outcomes were observed between the FOLFIRI plus cetuximab and FOLFIRI plus bevacizumab arms of FIRE-3. A significant interaction was observed between primary tumor location and treatment for OS (CRYSTAL: hazard ratio [HR], 1.95; 95% CI, 1.09-3.48 and FIRE-3: HR, 0.40; 95% CI, 0.23-0.70) within the<i>RAS</i>wt populations of both studies in multivariable models that also included sex, prior adjuvant therapy, and<i>BRAF</i>mutational status. <h3>Conclusions and Relevance</h3> In the<i>RAS </i>wt populations of CRYSTAL and FIRE-3, patients with left-sided tumors had a markedly better prognosis than those with right-sided tumors. First-line FOLFIRI plus cetuximab clearly benefitted patients with left-sided tumors (vs FOLFIRI or FOLFIRI plus bevacizumab, respectively), whereas patients with right-sided tumors derived limited benefit from standard treatments. <h3>Trial Registration</h3> clinicaltrials.gov Identifiers: CRYSTAL,NCT00154102, and FIRE-3,NCT00433927" @default.
• W2531319683 created "2016-10-21" @default.
• W2531319683 creator A5015190461 @default.
• W2531319683 creator A5027182289 @default.
• W2531319683 creator A5028841026 @default.
• W2531319683 creator A5037754184 @default.
• W2531319683 creator A5045441776 @default.
• W2531319683 creator A5056034569 @default.
• W2531319683 creator A5077359949 @default.
• W2531319683 creator A5087035379 @default.
• W2531319683 creator A5090645179 @default.
• W2531319683 date "2017-02-01" @default.
• W2531319683 modified "2023-10-17" @default.
• W2531319683 title "Prognostic and Predictive Relevance of Primary Tumor Location in Patients With <i>RAS </i>Wild-Type Metastatic Colorectal Cancer" @default.
• W2531319683 cites W1799482054 @default.
• W2531319683 cites W1908989187 @default.
• W2531319683 cites W1934094702 @default.
• W2531319683 cites W1940241680 @default.
• W2531319683 cites W2005348280 @default.
• W2531319683 cites W2032891420 @default.
• W2531319683 cites W2044022855 @default.
• W2531319683 cites W2051550002 @default.
• W2531319683 cites W2095201384 @default.
• W2531319683 cites W2112570485 @default.
• W2531319683 cites W2113029107 @default.
• W2531319683 cites W2125402320 @default.
• W2531319683 cites W2134142320 @default.
• W2531319683 cites W2146350639 @default.
• W2531319683 cites W2152205589 @default.
• W2531319683 cites W2153031009 @default.
• W2531319683 cites W2528475762 @default.
• W2531319683 cites W607572075 @default.
• W2531319683 doi "https://doi.org/10.1001/jamaoncol.2016.3797" @default.
• W2531319683 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7505121" @default.
• W2531319683 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27722750" @default.
• W2531319683 hasPublicationYear "2017" @default.
• W2531319683 type Work @default.
• W2531319683 sameAs 2531319683 @default.
• W2531319683 citedByCount "508" @default.
• W2531319683 countsByYear W25313196832016 @default.
• W2531319683 countsByYear W25313196832017 @default.
• W2531319683 countsByYear W25313196832018 @default.
• W2531319683 countsByYear W25313196832019 @default.
• W2531319683 countsByYear W25313196832020 @default.
• W2531319683 countsByYear W25313196832021 @default.
• W2531319683 countsByYear W25313196832022 @default.
• W2531319683 countsByYear W25313196832023 @default.
• W2531319683 crossrefType "journal-article" @default.
• W2531319683 hasAuthorship W2531319683A5015190461 @default.
• W2531319683 hasAuthorship W2531319683A5027182289 @default.
• W2531319683 hasAuthorship W2531319683A5028841026 @default.
• W2531319683 hasAuthorship W2531319683A5037754184 @default.
• W2531319683 hasAuthorship W2531319683A5045441776 @default.
• W2531319683 hasAuthorship W2531319683A5056034569 @default.
• W2531319683 hasAuthorship W2531319683A5077359949 @default.
• W2531319683 hasAuthorship W2531319683A5087035379 @default.
• W2531319683 hasAuthorship W2531319683A5090645179 @default.
• W2531319683 hasBestOaLocation W25313196832 @default.
• W2531319683 hasConcept C121608353 @default.
• W2531319683 hasConcept C126322002 @default.
• W2531319683 hasConcept C143998085 @default.
• W2531319683 hasConcept C2776694085 @default.
• W2531319683 hasConcept C2776705615 @default.
• W2531319683 hasConcept C2777802072 @default.
• W2531319683 hasConcept C2778292851 @default.
• W2531319683 hasConcept C2778435480 @default.
• W2531319683 hasConcept C2779013556 @default.
• W2531319683 hasConcept C2779998722 @default.
• W2531319683 hasConcept C2780259306 @default.
• W2531319683 hasConcept C2780283643 @default.
• W2531319683 hasConcept C2780833581 @default.
• W2531319683 hasConcept C2781074409 @default.
• W2531319683 hasConcept C3019760618 @default.
• W2531319683 hasConcept C526805850 @default.
• W2531319683 hasConcept C71924100 @default.
• W2531319683 hasConcept C90924648 @default.
• W2531319683 hasConceptScore W2531319683C121608353 @default.
• W2531319683 hasConceptScore W2531319683C126322002 @default.
• W2531319683 hasConceptScore W2531319683C143998085 @default.
• W2531319683 hasConceptScore W2531319683C2776694085 @default.
• W2531319683 hasConceptScore W2531319683C2776705615 @default.
• W2531319683 hasConceptScore W2531319683C2777802072 @default.
• W2531319683 hasConceptScore W2531319683C2778292851 @default.
• W2531319683 hasConceptScore W2531319683C2778435480 @default.
• W2531319683 hasConceptScore W2531319683C2779013556 @default.
• W2531319683 hasConceptScore W2531319683C2779998722 @default.
• W2531319683 hasConceptScore W2531319683C2780259306 @default.
• W2531319683 hasConceptScore W2531319683C2780283643 @default.
• W2531319683 hasConceptScore W2531319683C2780833581 @default.
• W2531319683 hasConceptScore W2531319683C2781074409 @default.
• W2531319683 hasConceptScore W2531319683C3019760618 @default.
• W2531319683 hasConceptScore W2531319683C526805850 @default.
• W2531319683 hasConceptScore W2531319683C71924100 @default.
• W2531319683 hasConceptScore W2531319683C90924648 @default.
• W2531319683 hasIssue "2" @default.
• W2531319683 hasLocation W25313196831 @default.
• W2531319683 hasLocation W25313196832 @default.
• W2531319683 hasLocation W25313196833 @default.

• next