Matches in SemOpenAlex for { <https://semopenalex.org/work/W2531326692> ?p ?o ?g. }
- W2531326692 endingPage "11" @default.
- W2531326692 startingPage "1" @default.
- W2531326692 abstract "Objective . Esophageal carcinoma (EC) is a frequently common malignancy of gastrointestinal cancer in the world. This study aims to screen key genes and pathways in EC and elucidate the mechanism of it. Methods . 5 microarray datasets of EC were downloaded from Gene Expression Omnibus. Differentially expressed genes (DEGs) were screened by bioinformatics analysis. Gene Ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment, and protein-protein interaction (PPI) network construction were performed to obtain the biological roles of DEGs in EC. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to verify the expression level of DEGs in EC. Results . A total of 1955 genes were filtered as DEGs in EC. The upregulated genes were significantly enriched in cell cycle and the downregulated genes significantly enriched in Endocytosis. PPI network displayed CDK4 and CCT3 were hub proteins in the network. The expression level of 8 dysregulated DEGs including CDK4, CCT3, THSD4, SIM2, MYBL2, CENPF, CDCA3, and CDKN3 was validated in EC compared to adjacent nontumor tissues and the results were matched with the microarray analysis. Conclusion . The significantly DEGs including CDK4, CCT3, THSD4, and SIM2 may play key roles in tumorigenesis and development of EC involved in cell cycle and Endocytosis." @default.
- W2531326692 created "2016-10-21" @default.
- W2531326692 creator A5000645208 @default.
- W2531326692 creator A5004227463 @default.
- W2531326692 creator A5006161030 @default.
- W2531326692 creator A5015436826 @default.
- W2531326692 creator A5021761346 @default.
- W2531326692 creator A5026850593 @default.
- W2531326692 creator A5053438827 @default.
- W2531326692 creator A5053447705 @default.
- W2531326692 creator A5055855869 @default.
- W2531326692 creator A5066648451 @default.
- W2531326692 date "2016-01-01" @default.
- W2531326692 modified "2023-09-22" @default.
- W2531326692 title "Identification of the Key Genes and Pathways in Esophageal Carcinoma" @default.
- W2531326692 cites W1538761388 @default.
- W2531326692 cites W1855071843 @default.
- W2531326692 cites W1857435742 @default.
- W2531326692 cites W1972645690 @default.
- W2531326692 cites W1977384381 @default.
- W2531326692 cites W1983074119 @default.
- W2531326692 cites W2002709014 @default.
- W2531326692 cites W2017908215 @default.
- W2531326692 cites W2019856979 @default.
- W2531326692 cites W2043483481 @default.
- W2531326692 cites W2063212204 @default.
- W2531326692 cites W2071282976 @default.
- W2531326692 cites W2073061004 @default.
- W2531326692 cites W2079288043 @default.
- W2531326692 cites W2097795961 @default.
- W2531326692 cites W2101207841 @default.
- W2531326692 cites W2103017472 @default.
- W2531326692 cites W2114570899 @default.
- W2531326692 cites W2116634113 @default.
- W2531326692 cites W2123060905 @default.
- W2531326692 cites W2125193443 @default.
- W2531326692 cites W2125358852 @default.
- W2531326692 cites W2132409312 @default.
- W2531326692 cites W2145936567 @default.
- W2531326692 cites W2148240072 @default.
- W2531326692 cites W2150514055 @default.
- W2531326692 cites W2153751115 @default.
- W2531326692 cites W2159675211 @default.
- W2531326692 cites W2165254414 @default.
- W2531326692 cites W2165948908 @default.
- W2531326692 cites W2167663414 @default.
- W2531326692 cites W2169840774 @default.
- W2531326692 cites W2197119872 @default.
- W2531326692 cites W2198223152 @default.
- W2531326692 cites W2272984102 @default.
- W2531326692 cites W2291490667 @default.
- W2531326692 cites W2315985241 @default.
- W2531326692 cites W2317957013 @default.
- W2531326692 cites W2395739137 @default.
- W2531326692 cites W2402619004 @default.
- W2531326692 cites W2915975108 @default.
- W2531326692 cites W4252560545 @default.
- W2531326692 cites W561809727 @default.
- W2531326692 cites W2135922299 @default.
- W2531326692 doi "https://doi.org/10.1155/2016/2968106" @default.
- W2531326692 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5080515" @default.
- W2531326692 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27818681" @default.
- W2531326692 hasPublicationYear "2016" @default.
- W2531326692 type Work @default.
- W2531326692 sameAs 2531326692 @default.
- W2531326692 citedByCount "17" @default.
- W2531326692 countsByYear W25313266922018 @default.
- W2531326692 countsByYear W25313266922019 @default.
- W2531326692 countsByYear W25313266922020 @default.
- W2531326692 countsByYear W25313266922021 @default.
- W2531326692 countsByYear W25313266922022 @default.
- W2531326692 crossrefType "journal-article" @default.
- W2531326692 hasAuthorship W2531326692A5000645208 @default.
- W2531326692 hasAuthorship W2531326692A5004227463 @default.
- W2531326692 hasAuthorship W2531326692A5006161030 @default.
- W2531326692 hasAuthorship W2531326692A5015436826 @default.
- W2531326692 hasAuthorship W2531326692A5021761346 @default.
- W2531326692 hasAuthorship W2531326692A5026850593 @default.
- W2531326692 hasAuthorship W2531326692A5053438827 @default.
- W2531326692 hasAuthorship W2531326692A5053447705 @default.
- W2531326692 hasAuthorship W2531326692A5055855869 @default.
- W2531326692 hasAuthorship W2531326692A5066648451 @default.
- W2531326692 hasBestOaLocation W25313266921 @default.
- W2531326692 hasConcept C104317684 @default.
- W2531326692 hasConcept C127561419 @default.
- W2531326692 hasConcept C150194340 @default.
- W2531326692 hasConcept C152724338 @default.
- W2531326692 hasConcept C186836561 @default.
- W2531326692 hasConcept C29537977 @default.
- W2531326692 hasConcept C2987395477 @default.
- W2531326692 hasConcept C502942594 @default.
- W2531326692 hasConcept C54355233 @default.
- W2531326692 hasConcept C555283112 @default.
- W2531326692 hasConcept C60644358 @default.
- W2531326692 hasConcept C70721500 @default.
- W2531326692 hasConcept C8415881 @default.
- W2531326692 hasConcept C86803240 @default.
- W2531326692 hasConceptScore W2531326692C104317684 @default.