FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2531328373> ?p ?o ?g. }

• W2531328373 endingPage "652" @default.
• W2531328373 startingPage "645" @default.
• W2531328373 abstract "ABSTRACT Background: Converging evidence suggests that subjective cognitive concerns (SCC) are associated with biomarker evidence of Alzheimer's disease (AD) prior to objective clinical impairment. However, the sensitivity of SCC reports in early AD may be biased by demographic factors. Here, we sought to investigate whether age, education, and sex influence the relationship between SCC and amyloid (Aβ) burden. Methods: In this cross-sectional study, we examined 252 clinically normal (CN) individuals (57.7% females) enrolled in the Harvard Aging Brain Study, ages 63–90 years (mean 73.7±6) with 6–20 years of education (mean 15.8±3). SCC was assessed as a composite score comprising three questionnaires. Cortical Aβ burden was assessed with Pittsburgh compound B positron emission tomography imaging. A series of linear regression models assessed the potential modifying role of demographic variables with respect to Aβ burden and SCC. A post-hoc mediation model was implemented to further understand the relationship between Aβ burden and SCC via their relationship with education. Results: Age (β = −0.84, p = 0.36) and sex (β = −0.55, p = 0.22) did not modify the relationship between SCC and Aβ burden. Fewer years of education was correlated with greater SCC ( r = −0.12, p = 0.05), but the relationship between Aβ burden and SCC was stronger in those with more education (β = 1.16, p < 0.05). A partial mediation effect was found of Aβ burden on SCC via education ( b = −0.12, 95% CI [−0.31, −0.02]). Conclusions: These findings suggest that the association between SCC and Aβ burden becomes stronger with greater educational attainment. Thus, SCC may be of particular importance in highly educated CN individuals harboring amyloid pathology." @default.
• W2531328373 created "2016-10-21" @default.
• W2531328373 creator A5001795846 @default.
• W2531328373 creator A5044228617 @default.
• W2531328373 creator A5057415951 @default.
• W2531328373 creator A5074658251 @default.
• W2531328373 creator A5076768887 @default.
• W2531328373 creator A5084568106 @default.
• W2531328373 creator A5087983425 @default.
• W2531328373 creator A5090842068 @default.
• W2531328373 date "2016-10-11" @default.
• W2531328373 modified "2023-09-30" @default.
• W2531328373 title "The influence of demographic factors on subjective cognitive concerns and beta-amyloid" @default.
• W2531328373 cites W1505300817 @default.
• W2531328373 cites W1523725480 @default.
• W2531328373 cites W1542836096 @default.
• W2531328373 cites W1569100977 @default.
• W2531328373 cites W1773491060 @default.
• W2531328373 cites W1847168837 @default.
• W2531328373 cites W1971351343 @default.
• W2531328373 cites W1979636244 @default.
• W2531328373 cites W1980111435 @default.
• W2531328373 cites W1984978256 @default.
• W2531328373 cites W1987542199 @default.
• W2531328373 cites W1991952617 @default.
• W2531328373 cites W1995779519 @default.
• W2531328373 cites W1997807985 @default.
• W2531328373 cites W2001878678 @default.
• W2531328373 cites W2004344916 @default.
• W2531328373 cites W2008854521 @default.
• W2531328373 cites W2024379180 @default.
• W2531328373 cites W2037789466 @default.
• W2531328373 cites W2048505725 @default.
• W2531328373 cites W2057158160 @default.
• W2531328373 cites W2058161128 @default.
• W2531328373 cites W2078184061 @default.
• W2531328373 cites W2079493264 @default.
• W2531328373 cites W2079669672 @default.
• W2531328373 cites W2112519660 @default.
• W2531328373 cites W2115300091 @default.
• W2531328373 cites W2142904655 @default.
• W2531328373 cites W2148080316 @default.
• W2531328373 cites W2151986002 @default.
• W2531328373 cites W2152223730 @default.
• W2531328373 cites W2155126658 @default.
• W2531328373 cites W2162666574 @default.
• W2531328373 cites W2167311298 @default.
• W2531328373 cites W2176398638 @default.
• W2531328373 cites W2210563386 @default.
• W2531328373 cites W323706521 @default.
• W2531328373 cites W4233768626 @default.
• W2531328373 cites W4251404648 @default.
• W2531328373 doi "https://doi.org/10.1017/s1041610216001502" @default.
• W2531328373 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5361739" @default.
• W2531328373 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27724996" @default.
• W2531328373 hasPublicationYear "2016" @default.
• W2531328373 type Work @default.
• W2531328373 sameAs 2531328373 @default.
• W2531328373 citedByCount "15" @default.
• W2531328373 countsByYear W25313283732017 @default.
• W2531328373 countsByYear W25313283732019 @default.
• W2531328373 countsByYear W25313283732021 @default.
• W2531328373 countsByYear W25313283732022 @default.
• W2531328373 countsByYear W25313283732023 @default.
• W2531328373 crossrefType "journal-article" @default.
• W2531328373 hasAuthorship W2531328373A5001795846 @default.
• W2531328373 hasAuthorship W2531328373A5044228617 @default.
• W2531328373 hasAuthorship W2531328373A5057415951 @default.
• W2531328373 hasAuthorship W2531328373A5074658251 @default.
• W2531328373 hasAuthorship W2531328373A5076768887 @default.
• W2531328373 hasAuthorship W2531328373A5084568106 @default.
• W2531328373 hasAuthorship W2531328373A5087983425 @default.
• W2531328373 hasAuthorship W2531328373A5090842068 @default.
• W2531328373 hasBestOaLocation W25313283732 @default.
• W2531328373 hasConcept C118552586 @default.
• W2531328373 hasConcept C126322002 @default.
• W2531328373 hasConcept C143998085 @default.
• W2531328373 hasConcept C144024400 @default.
• W2531328373 hasConcept C149923435 @default.
• W2531328373 hasConcept C15744967 @default.
• W2531328373 hasConcept C169900460 @default.
• W2531328373 hasConcept C17744445 @default.
• W2531328373 hasConcept C179420905 @default.
• W2531328373 hasConcept C199539241 @default.
• W2531328373 hasConcept C2779134260 @default.
• W2531328373 hasConcept C2779483572 @default.
• W2531328373 hasConcept C2781073650 @default.
• W2531328373 hasConcept C2781197716 @default.
• W2531328373 hasConcept C2984863031 @default.
• W2531328373 hasConcept C502032728 @default.
• W2531328373 hasConcept C55493867 @default.
• W2531328373 hasConcept C70410870 @default.
• W2531328373 hasConcept C71924100 @default.
• W2531328373 hasConcept C74909509 @default.
• W2531328373 hasConcept C86803240 @default.
• W2531328373 hasConceptScore W2531328373C118552586 @default.
• W2531328373 hasConceptScore W2531328373C126322002 @default.
• W2531328373 hasConceptScore W2531328373C143998085 @default.

• next