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- W2531335004 abstract "Mesothelin is a tumor antigen that is highly expressed in many human cancers, including malignant mesothelioma and pancreatic, ovarian, and lung adenocarcinomas. It is an attractive target for cancer immunotherapy because its normal expression is limited to mesothelial cells, which are dispensable. Several antibody-based therapeutic agents as well as vaccine and T-cell therapies directed at mesothelin are undergoing clinical evaluation. These include antimesothelin immunotoxins (SS1P, RG7787/LMB-100), chimeric antimesothelin antibody (amatuximab), mesothelin-directed antibody drug conjugates (anetumab ravtansine, DMOT4039A, BMS-986148), live attenuated Listeria monocytogenes-expressing mesothelin (CRS-207, JNJ-64041757), and chimeric antigen receptor T-cell therapies. Two antimesothelin agents are currently in multicenter clinical registration trials for malignant mesothelioma: amatuximab in the first-line setting and anetumab ravtansine as second-line therapy. Phase II randomized clinical trials of CRS-207 as a boosting agent and in combination with immune checkpoint inhibition for pancreatic cancer are nearing completion. These ongoing studies will define the utility of mesothelin immunotherapy for treating cancer." @default.
- W2531335004 created "2016-10-21" @default.
- W2531335004 creator A5011776853 @default.
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- W2531335004 creator A5056573254 @default.
- W2531335004 creator A5074644543 @default.
- W2531335004 date "2016-12-01" @default.
- W2531335004 modified "2023-10-16" @default.
- W2531335004 title "Mesothelin Immunotherapy for Cancer: Ready for Prime Time?" @default.
- W2531335004 cites W138135214 @default.
- W2531335004 cites W1503438909 @default.
- W2531335004 cites W1505618476 @default.
- W2531335004 cites W1607832269 @default.
- W2531335004 cites W1871670984 @default.
- W2531335004 cites W1926256541 @default.
- W2531335004 cites W1940023041 @default.
- W2531335004 cites W1966327293 @default.
- W2531335004 cites W1967044436 @default.
- W2531335004 cites W1969194497 @default.
- W2531335004 cites W1971041510 @default.
- W2531335004 cites W1977122810 @default.
- W2531335004 cites W1978653793 @default.
- W2531335004 cites W1979568379 @default.
- W2531335004 cites W1984369885 @default.
- W2531335004 cites W1987100568 @default.
- W2531335004 cites W1987305699 @default.
- W2531335004 cites W1988226553 @default.
- W2531335004 cites W1994686262 @default.
- W2531335004 cites W1996558981 @default.
- W2531335004 cites W2000338643 @default.
- W2531335004 cites W2003541535 @default.
- W2531335004 cites W2008652001 @default.
- W2531335004 cites W2009013652 @default.
- W2531335004 cites W2022320119 @default.
- W2531335004 cites W2029763480 @default.
- W2531335004 cites W2030235885 @default.
- W2531335004 cites W2031243108 @default.
- W2531335004 cites W2035038195 @default.
- W2531335004 cites W2040500107 @default.
- W2531335004 cites W2044637198 @default.
- W2531335004 cites W2046654082 @default.
- W2531335004 cites W2050396069 @default.
- W2531335004 cites W2050658031 @default.
- W2531335004 cites W2054308733 @default.
- W2531335004 cites W2060830492 @default.
- W2531335004 cites W2062826077 @default.
- W2531335004 cites W2065248620 @default.
- W2531335004 cites W2072567920 @default.
- W2531335004 cites W2075997128 @default.
- W2531335004 cites W2082115360 @default.
- W2531335004 cites W2087508074 @default.
- W2531335004 cites W2088482301 @default.
- W2531335004 cites W2093741293 @default.
- W2531335004 cites W2097734025 @default.
- W2531335004 cites W2098419540 @default.
- W2531335004 cites W2101371847 @default.
- W2531335004 cites W2102073127 @default.
- W2531335004 cites W2102596101 @default.
- W2531335004 cites W2106775454 @default.
- W2531335004 cites W2110239006 @default.
- W2531335004 cites W2113480269 @default.
- W2531335004 cites W2117688944 @default.
- W2531335004 cites W2121834538 @default.
- W2531335004 cites W2124757685 @default.
- W2531335004 cites W2124837438 @default.
- W2531335004 cites W2128903029 @default.
- W2531335004 cites W2131809958 @default.
- W2531335004 cites W2132417559 @default.
- W2531335004 cites W2133298966 @default.
- W2531335004 cites W2134786525 @default.
- W2531335004 cites W2135339053 @default.
- W2531335004 cites W2138284300 @default.
- W2531335004 cites W2138654358 @default.
- W2531335004 cites W2139794819 @default.
- W2531335004 cites W2140317464 @default.
- W2531335004 cites W2150869832 @default.
- W2531335004 cites W2151021631 @default.
- W2531335004 cites W2152589130 @default.
- W2531335004 cites W2153375051 @default.
- W2531335004 cites W2154363908 @default.
- W2531335004 cites W2155523020 @default.
- W2531335004 cites W2158059172 @default.
- W2531335004 cites W2160261768 @default.
- W2531335004 cites W2167461988 @default.
- W2531335004 cites W2168453763 @default.
- W2531335004 cites W2169876627 @default.
- W2531335004 cites W2172175430 @default.
- W2531335004 cites W2194126106 @default.
- W2531335004 cites W2197484396 @default.
- W2531335004 cites W2199851823 @default.
- W2531335004 cites W2286655178 @default.
- W2531335004 cites W2286884046 @default.
- W2531335004 cites W2297008886 @default.
- W2531335004 cites W2316929473 @default.
- W2531335004 cites W2398340530 @default.
- W2531335004 doi "https://doi.org/10.1200/jco.2016.68.3672" @default.