FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2531364014> ?p ?o ?g. }

• W2531364014 endingPage "2089" @default.
• W2531364014 startingPage "2078" @default.
• W2531364014 abstract "Phosphodiesterase 4 (PDE4) inhibitors are approved for the treatment of some moderate to severe inflammatory conditions. However, dose-limiting side effects in the central nervous system and gastrointestinal tract, including nausea, emesis, headache, and diarrhea, have impeded the broader therapeutic application of PDE4 inhibitors. We sought to exploit the wealth of validation surrounding PDE4 inhibition by improving the therapeutic index through generation of an antibody-drug conjugate (ADC) that selectively targets immune cells through the CD11a antigen. The resulting ADC consisted of a human αCD11a antibody (based on efalizumab clone hu1124) conjugated to an analog of the highly potent PDE4 inhibitor GSK256066. Both the human αCD11a ADC and a mouse surrogate αCD11a ADC (based on the M17 clone) rapidly internalized into immune cells and suppressed lipololysaccharide (LPS)-induced TNFα secretion in primary human monocytes and mouse peritoneal cells, respectively. In a carrageenan-induced air pouch inflammation mouse model, treatment with the ADC significantly reduced inflammatory cytokine production in the air pouch exudate. Overall, these results provide compelling evidence for the feasibility of delivering drugs with anti-inflammatory activity selectively to the immune compartment via CD11a and the development of tissue-targeted PDE4 inhibitors as a promising therapeutic modality for treating inflammatory diseases." @default.
• W2531364014 created "2016-10-21" @default.
• W2531364014 creator A5000151427 @default.
• W2531364014 creator A5004885927 @default.
• W2531364014 creator A5009038754 @default.
• W2531364014 creator A5019594783 @default.
• W2531364014 creator A5028788457 @default.
• W2531364014 creator A5042497632 @default.
• W2531364014 creator A5047954931 @default.
• W2531364014 creator A5050858216 @default.
• W2531364014 creator A5051765438 @default.
• W2531364014 creator A5057189685 @default.
• W2531364014 creator A5060471020 @default.
• W2531364014 creator A5066008654 @default.
• W2531364014 creator A5066259889 @default.
• W2531364014 creator A5067991376 @default.
• W2531364014 creator A5079931299 @default.
• W2531364014 creator A5081692463 @default.
• W2531364014 creator A5085073120 @default.
• W2531364014 creator A5090934036 @default.
• W2531364014 date "2016-12-01" @default.
• W2531364014 modified "2023-10-18" @default.
• W2531364014 title "Targeted Delivery of an Anti-inflammatory PDE4 Inhibitor to Immune Cells via an Antibody–drug Conjugate" @default.
• W2531364014 cites W1621017507 @default.
• W2531364014 cites W1758317174 @default.
• W2531364014 cites W1919283206 @default.
• W2531364014 cites W1967221897 @default.
• W2531364014 cites W1972029787 @default.
• W2531364014 cites W1975780666 @default.
• W2531364014 cites W2028043561 @default.
• W2531364014 cites W2030133200 @default.
• W2531364014 cites W2034382557 @default.
• W2531364014 cites W2036637485 @default.
• W2531364014 cites W2049107598 @default.
• W2531364014 cites W2058332629 @default.
• W2531364014 cites W2061453556 @default.
• W2531364014 cites W2067024114 @default.
• W2531364014 cites W2081656524 @default.
• W2531364014 cites W2085471242 @default.
• W2531364014 cites W2086790377 @default.
• W2531364014 cites W2088957014 @default.
• W2531364014 cites W2094584583 @default.
• W2531364014 cites W2097771640 @default.
• W2531364014 cites W2101175089 @default.
• W2531364014 cites W2108671666 @default.
• W2531364014 cites W2120871937 @default.
• W2531364014 cites W2123066014 @default.
• W2531364014 cites W2125750090 @default.
• W2531364014 cites W2140463009 @default.
• W2531364014 cites W2151783961 @default.
• W2531364014 cites W2151978506 @default.
• W2531364014 cites W2154616892 @default.
• W2531364014 cites W2166511920 @default.
• W2531364014 cites W2278078807 @default.
• W2531364014 cites W2316775858 @default.
• W2531364014 cites W4237807778 @default.
• W2531364014 doi "https://doi.org/10.1038/mt.2016.175" @default.
• W2531364014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5167782" @default.
• W2531364014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27731313" @default.
• W2531364014 hasPublicationYear "2016" @default.
• W2531364014 type Work @default.
• W2531364014 sameAs 2531364014 @default.
• W2531364014 citedByCount "30" @default.
• W2531364014 countsByYear W25313640142017 @default.
• W2531364014 countsByYear W25313640142018 @default.
• W2531364014 countsByYear W25313640142019 @default.
• W2531364014 countsByYear W25313640142020 @default.
• W2531364014 countsByYear W25313640142021 @default.
• W2531364014 countsByYear W25313640142022 @default.
• W2531364014 countsByYear W25313640142023 @default.
• W2531364014 crossrefType "journal-article" @default.
• W2531364014 hasAuthorship W2531364014A5000151427 @default.
• W2531364014 hasAuthorship W2531364014A5004885927 @default.
• W2531364014 hasAuthorship W2531364014A5009038754 @default.
• W2531364014 hasAuthorship W2531364014A5019594783 @default.
• W2531364014 hasAuthorship W2531364014A5028788457 @default.
• W2531364014 hasAuthorship W2531364014A5042497632 @default.
• W2531364014 hasAuthorship W2531364014A5047954931 @default.
• W2531364014 hasAuthorship W2531364014A5050858216 @default.
• W2531364014 hasAuthorship W2531364014A5051765438 @default.
• W2531364014 hasAuthorship W2531364014A5057189685 @default.
• W2531364014 hasAuthorship W2531364014A5060471020 @default.
• W2531364014 hasAuthorship W2531364014A5066008654 @default.
• W2531364014 hasAuthorship W2531364014A5066259889 @default.
• W2531364014 hasAuthorship W2531364014A5067991376 @default.
• W2531364014 hasAuthorship W2531364014A5079931299 @default.
• W2531364014 hasAuthorship W2531364014A5081692463 @default.
• W2531364014 hasAuthorship W2531364014A5085073120 @default.
• W2531364014 hasAuthorship W2531364014A5090934036 @default.
• W2531364014 hasBestOaLocation W25313640141 @default.
• W2531364014 hasConcept C159654299 @default.
• W2531364014 hasConcept C203014093 @default.
• W2531364014 hasConcept C2776914184 @default.
• W2531364014 hasConcept C71924100 @default.
• W2531364014 hasConcept C8891405 @default.
• W2531364014 hasConcept C98274493 @default.
• W2531364014 hasConceptScore W2531364014C159654299 @default.
• W2531364014 hasConceptScore W2531364014C203014093 @default.

• next