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- W2531399145 abstract "A 10-fold circadian variation in the amount of luciferin binding protein (LBP) in the marine dinoflagellate Gonyaulax polyedra is reported. This protein binds and stabil- izes luciferin, the bioluminescence substrate. In early night phase, when bioluminescence is increasing and LBP levels are rising in the cell, pulse labeling experiments show that LBP is being rapidly synthesized in vivo. At other times, the rate of LBP synthesis is at least 50 times lower, while the rate of synthesis of most other proteins remains the same. The LBP mRNA levels, as determined by in vitro translations and by RNA (Northern) hybridizations, do not vary over the daily cycle, indicating that circadian control of bioluminescence in this species is mediated by translation. In the unicellular marine alga Gonyaulax polyedra, many properties of the cells change frpm day to night, representing, in effect, a cyclic daily differentiation. Such circadian (daily) rhythms continue under constant conditions (e.g., light and temperature) and occur widely in eukaryotes from humans to microorganisms (1). Although believed to be of fundamental importance in the control of diverse processes, neither the biochemical components nor the cellular organization of the underlying oscillatory mechanism is known in any system. Bioluminescence in G. polyedra is a circadian controlled process, occurring predominately during the organism's night phase (2). The cellular capacity for bioluminescence is directly correlated with the presence of the biochemical components involved in the in vitro light-producing reaction: dinoflagellate luciferin, a fluorescent oxidizable substrate noncovalently bound to a luciferin binding protein (LBP), and an enzyme (luciferase) catalyzing the light-producing reac- tion. Both the luciferin and the luciferase have been shown to undergo circadian variation in amounts with 10-fold higher concentrations of both present in the middle of the subjective night (3-6). Gonyaulax is the only system known to date in which a circadian controlled process-namely, bioluminescence- has been shown to correlate with both changes in the activity and absolute levels of a protein-namely, the luciferase (4, 5). We have extended these observations to LBP with two important additions. First, we show that the increase in LBP levels results from a transient increase in the rate of synthesis of the protein and, second, that these changes in synthetic rate are apparently due to a translational control mechanism." @default.
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- W2531399145 date "2016-01-01" @default.
- W2531399145 modified "2023-09-27" @default.
- W2531399145 title "Circadian regulation of bioluminescence in Gonyaulax involves" @default.
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