Matches in SemOpenAlex for { <https://semopenalex.org/work/W2531402283> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2531402283 endingPage "5354" @default.
- W2531402283 startingPage "5347" @default.
- W2531402283 abstract "We reported that vitamin D3 increased transforming growth factor (TGF)β2 and decreased prostaglandin (PG)E2 in the breast of normal-risk women, suggesting a protective effect. We determined if the findings held for higher risk women.Seventy-eight women received daily for one month/menstrual cycle: placebo, 400 international units (IU) vitamin D3, 2,000 IU vitamin D3 or 2,000 IU vitamin D3/400 mg celecoxib. Nipple aspirate fluid (NAF) and/or serum were analyzed for PGE2, TGFβ1,-2, vitaminD binding protein (DBP) 25(OH)D; and plasma for celecoxib.25(OH)D increased (p<0.001) in women receiving 2,000 IU vitamin D3. Two thousand IU vitamin D3 lowered NAF PGE2 in normal-risk women (p=0.029), whereas 2,000 IU vitamin D3/celecoxib lowered NAF PGE2 in high-risk women (p=0.063). Serum TGFβ1 was influenced by treatment (p=0.011). NAF TGFβ2 increase correlated with increase in 25(OH)D. DBP serum levels were higher than matched NAF, regardless of race, and did not appreciably change with treatment.Vitamin D3 influenced TGFβ1 and -β2 expression. PGE2 response to vitamin D3 treatment was influenced by a participant's breast cancer risk. The implications of these observations regarding breast cancer risk should be further evaluated." @default.
- W2531402283 created "2016-10-21" @default.
- W2531402283 creator A5018394997 @default.
- W2531402283 creator A5043556576 @default.
- W2531402283 creator A5053935340 @default.
- W2531402283 creator A5079985926 @default.
- W2531402283 creator A5080468872 @default.
- W2531402283 date "2016-10-12" @default.
- W2531402283 modified "2023-10-12" @default.
- W2531402283 title "Vitamin D3 Treatment Influences PGE2 and TGFβ in Normal and Increased Breast Cancer Risk Women" @default.
- W2531402283 doi "https://doi.org/10.21873/anticanres.11108" @default.
- W2531402283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27798898" @default.
- W2531402283 hasPublicationYear "2016" @default.
- W2531402283 type Work @default.
- W2531402283 sameAs 2531402283 @default.
- W2531402283 citedByCount "4" @default.
- W2531402283 countsByYear W25314022832017 @default.
- W2531402283 countsByYear W25314022832018 @default.
- W2531402283 countsByYear W25314022832019 @default.
- W2531402283 countsByYear W25314022832021 @default.
- W2531402283 crossrefType "journal-article" @default.
- W2531402283 hasAuthorship W2531402283A5018394997 @default.
- W2531402283 hasAuthorship W2531402283A5043556576 @default.
- W2531402283 hasAuthorship W2531402283A5053935340 @default.
- W2531402283 hasAuthorship W2531402283A5079985926 @default.
- W2531402283 hasAuthorship W2531402283A5080468872 @default.
- W2531402283 hasBestOaLocation W25314022831 @default.
- W2531402283 hasConcept C121608353 @default.
- W2531402283 hasConcept C124490489 @default.
- W2531402283 hasConcept C126322002 @default.
- W2531402283 hasConcept C134018914 @default.
- W2531402283 hasConcept C142724271 @default.
- W2531402283 hasConcept C204787440 @default.
- W2531402283 hasConcept C27081682 @default.
- W2531402283 hasConcept C2776467144 @default.
- W2531402283 hasConcept C2776940978 @default.
- W2531402283 hasConcept C530470458 @default.
- W2531402283 hasConcept C71924100 @default.
- W2531402283 hasConceptScore W2531402283C121608353 @default.
- W2531402283 hasConceptScore W2531402283C124490489 @default.
- W2531402283 hasConceptScore W2531402283C126322002 @default.
- W2531402283 hasConceptScore W2531402283C134018914 @default.
- W2531402283 hasConceptScore W2531402283C142724271 @default.
- W2531402283 hasConceptScore W2531402283C204787440 @default.
- W2531402283 hasConceptScore W2531402283C27081682 @default.
- W2531402283 hasConceptScore W2531402283C2776467144 @default.
- W2531402283 hasConceptScore W2531402283C2776940978 @default.
- W2531402283 hasConceptScore W2531402283C530470458 @default.
- W2531402283 hasConceptScore W2531402283C71924100 @default.
- W2531402283 hasIssue "10" @default.
- W2531402283 hasLocation W25314022831 @default.
- W2531402283 hasLocation W25314022832 @default.
- W2531402283 hasOpenAccess W2531402283 @default.
- W2531402283 hasPrimaryLocation W25314022831 @default.
- W2531402283 hasRelatedWork W1566448015 @default.
- W2531402283 hasRelatedWork W1753513485 @default.
- W2531402283 hasRelatedWork W2000065095 @default.
- W2531402283 hasRelatedWork W2041750889 @default.
- W2531402283 hasRelatedWork W2094822922 @default.
- W2531402283 hasRelatedWork W2138174261 @default.
- W2531402283 hasRelatedWork W2153523313 @default.
- W2531402283 hasRelatedWork W2157304718 @default.
- W2531402283 hasRelatedWork W2165454093 @default.
- W2531402283 hasRelatedWork W2399836761 @default.
- W2531402283 hasRelatedWork W2400527478 @default.
- W2531402283 hasRelatedWork W2511140516 @default.
- W2531402283 hasRelatedWork W2592778689 @default.
- W2531402283 hasRelatedWork W2608205442 @default.
- W2531402283 hasRelatedWork W2625528629 @default.
- W2531402283 hasRelatedWork W2766232072 @default.
- W2531402283 hasRelatedWork W2934176591 @default.
- W2531402283 hasRelatedWork W3007371362 @default.
- W2531402283 hasRelatedWork W3018088051 @default.
- W2531402283 hasRelatedWork W3133418865 @default.
- W2531402283 hasVolume "36" @default.
- W2531402283 isParatext "false" @default.
- W2531402283 isRetracted "false" @default.
- W2531402283 magId "2531402283" @default.
- W2531402283 workType "article" @default.