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- W2531467400 abstract "K pneumoniae (KPn) is an important causative agent of nosocomial and community acquired pneumonia and sepsis. Although innate immune mechanisms play an important role in development of sepsis, these are not well defined in pathogenesis of KPn infection. The goal of this study was to elucidate the role of an innate immune C-type lectin receptor, Clec4d in pulmonary infection of mice with this pathogen. As such, the function of this receptor in host immunity to any infection is completely undefined. Here, we report that compared to the wild-type (WT) C57BL/6 mice, the Clec4d-/mice were highly susceptible to pulmonary infection with KPn and showed 100% mortality by day 4 of infection. This coincided with a higher bacterial burden in lungs, liver and blood of these mice as compared to their WT counterparts. While lungs of WT as well as Clec4d-/mice showed infiltration of neutrophils early during infection, the WT mice showed resolution of this cellular infiltration by day 3 p.i. whereas the Clec4d-/mice showed increased neutrophil infiltration and severe tissue pathology at that time p.i. in the lungs. This correlated with overwhelming levels of inflammatory cytokines in the knock-out mice reminiscent of hypercytokinemia, a characteristic feature of sepsis. These results demonstrate that Clec4d-associated responses modulate the disease severity and sepsis development during pulmonary infection with KPn. This is the first report of the role of Clec4d in a pulmonary infection model. Jyotika Sharma, J Clin Exp Pathol 2012, 2:5 http://dx.doi.org/10.4172/2161-0681.S1.003" @default.
- W2531467400 created "2016-10-21" @default.
- W2531467400 creator A5049676837 @default.
- W2531467400 date "2013-06-19" @default.
- W2531467400 modified "2023-09-23" @default.
- W2531467400 title "Novel role of a C-type lectin receptor in pulmonary klebsiella infection" @default.
- W2531467400 hasPublicationYear "2013" @default.
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